Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
20 04 2020
20 04 2020
Historique:
pubmed:
17
3
2020
medline:
3
7
2021
entrez:
17
3
2020
Statut:
ppublish
Résumé
Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the treatment of malignant tumors. The accepted mechanism of action of NM is through the alkylation of DNA bases. NM-adducts block DNA replication in cancer cells by forming cytotoxic DNA interstrand cross-links. We previously characterized several adducts formed by reaction of bis(2-chloroethyl)ethylamine (NM) with calf thymus (CT) DNA and the MDA-MB-231 mammary tumor cell line. The monoalkylated N7-guanine (NM-G) adduct and its cross-link (G-NM-G) were major lesions. The cationic NM-G undergoes a secondary reaction through depurination to form an apurinic (AP) site or reacts with hydroxide to yield the stable ring-opened
Identifiants
pubmed: 32174110
doi: 10.1021/acs.chemrestox.0c00012
pmc: PMC7266082
mid: NIHMS1582029
doi:
Substances chimiques
DNA Adducts
0
Mechlorethamine
50D9XSG0VR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
988-998Subventions
Organisme : NCI NIH HHS
ID : P01 CA160032
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
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