Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease.
asthma
heart rate variability
salbutamol
sickle cell disease
sympathetic activity
vagal activity
vaso-occlusive event
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
11
2019
accepted:
15
01
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
17
3
2020
Statut:
epublish
Résumé
Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the autonomic nervous system (ANS). Cross-sectional evaluation of heart rate variability (HRV) during pulmonary function tests, including salbutamol administration, in children with SCD receiving asthma treatment or not when compared to asthmatic children without SCD matched for ethnicity. SCD children with asthma ( SCD children are characterized by impaired parasympathetic control and sympathetic overactivity that is worsened by salbutamol administration. www.ClinicalTrials.gov, identifier NCT04062409.
Sections du résumé
BACKGROUND
BACKGROUND
Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the autonomic nervous system (ANS).
METHODS
METHODS
Cross-sectional evaluation of heart rate variability (HRV) during pulmonary function tests, including salbutamol administration, in children with SCD receiving asthma treatment or not when compared to asthmatic children without SCD matched for ethnicity.
RESULTS
RESULTS
SCD children with asthma (
CONCLUSION
CONCLUSIONS
SCD children are characterized by impaired parasympathetic control and sympathetic overactivity that is worsened by salbutamol administration.
CLINICAL TRIAL REGISTRATION
BACKGROUND
www.ClinicalTrials.gov, identifier NCT04062409.
Identifiants
pubmed: 32174840
doi: 10.3389/fphys.2020.00031
pmc: PMC7054439
doi:
Banques de données
ClinicalTrials.gov
['NCT04062409']
Types de publication
Journal Article
Langues
eng
Pagination
31Informations de copyright
Copyright © 2020 Bokov, El Jurdi, Denjoy, Peiffer, Medjahdi, Holvoet, Benkerrou and Delclaux.
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