Transcriptomic Study of Porcine Small Intestine Epithelial Cells Reveals Important Genes and Pathways Associated With Susceptibility to
ETEC F4ac fimbriae
RNA-Seq
diarrhea
intestine epithelial cells adhesion
piglet's susceptibility phenotype
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
08
2019
accepted:
20
01
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
17
3
2020
Statut:
epublish
Résumé
Diarrhea represents one of the most frequent major problems during piglets' neonatal and post-weaning periods leading to tremendous economic losses in the swine industry. Enterotoxigenic A total of eight samples of small intestine epithelial cells obtained from Large White piglets (35 days old) used in this study were selected on the basis of two criteria. One was the adhesion phenotype to ETEC-F4ac fimbriae, and the other was the comparison of More down-regulated DEGs (p < 0.05, |log The results provide insights on the biology of the phenotypes of F4R positive and negative pigs. One gene (
Sections du résumé
BACKGROUND
BACKGROUND
Diarrhea represents one of the most frequent major problems during piglets' neonatal and post-weaning periods leading to tremendous economic losses in the swine industry. Enterotoxigenic
METHODS
METHODS
A total of eight samples of small intestine epithelial cells obtained from Large White piglets (35 days old) used in this study were selected on the basis of two criteria. One was the adhesion phenotype to ETEC-F4ac fimbriae, and the other was the comparison of
RESULTS
RESULTS
More down-regulated DEGs (p < 0.05, |log
CONCLUSION
CONCLUSIONS
The results provide insights on the biology of the phenotypes of F4R positive and negative pigs. One gene (
Identifiants
pubmed: 32174961
doi: 10.3389/fgene.2020.00068
pmc: PMC7056726
doi:
Types de publication
Journal Article
Langues
eng
Pagination
68Informations de copyright
Copyright © 2020 Augustino, Xu, Liu, Liu, Zhang and Yu.
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