Toll signaling promotes JNK-dependent apoptosis in
Cell death
Drosophila
JNK
ROS
Toll
Journal
Cell division
ISSN: 1747-1028
Titre abrégé: Cell Div
Pays: England
ID NLM: 101251560
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
11
2019
accepted:
29
02
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
17
3
2020
Statut:
epublish
Résumé
Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient evolutionary origin, regulates embryonic dorsal-ventral patterning, axon targeting and degeneration, and innate immunity. Using We found that gain of Toll signaling is able to trigger caspase-dependent cell death in development. In addition, JNK activity is required for Toll-induced cell death. Furthermore, ectopic Toll expression induces the activation of JNK pathway. Moreover, physiological activation of Toll signaling is sufficient to produce JNK-dependent cell death. Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production. As Toll pathway has been evolutionarily conserved from
Sections du résumé
BACKGROUND
BACKGROUND
Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient evolutionary origin, regulates embryonic dorsal-ventral patterning, axon targeting and degeneration, and innate immunity. Using
RESULTS
RESULTS
We found that gain of Toll signaling is able to trigger caspase-dependent cell death in development. In addition, JNK activity is required for Toll-induced cell death. Furthermore, ectopic Toll expression induces the activation of JNK pathway. Moreover, physiological activation of Toll signaling is sufficient to produce JNK-dependent cell death. Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production.
CONCLUSIONS
CONCLUSIONS
As Toll pathway has been evolutionarily conserved from
Identifiants
pubmed: 32174999
doi: 10.1186/s13008-020-00062-5
pii: 62
pmc: PMC7063707
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
Références
Immunity. 2000 May;12(5):569-80
pubmed: 10843389
Genes Dev. 1996 Nov 1;10(21):2745-58
pubmed: 8946915
Nature. 2011 Apr 28;472(7344):476-80
pubmed: 21525932
Nature. 1998 Mar 5;392(6671):93-7
pubmed: 9510254
Development. 2018 Apr 25;145(9):
pubmed: 29695493
J Cell Biol. 2017 May 1;216(5):1421-1438
pubmed: 28373203
PLoS Genet. 2015 Oct 16;11(10):e1005589
pubmed: 26474173
Cell. 1996 Sep 20;86(6):973-83
pubmed: 8808632
Development. 1993 Nov;119(3):855-65
pubmed: 8187644
Cell Rep. 2018 Oct 9;25(2):437-448
pubmed: 30304683
Cell Death Differ. 2010 Mar;17(3):534-9
pubmed: 19960024
Nat Rev Mol Cell Biol. 2017 Feb;18(2):127-136
pubmed: 27999438
EMBO J. 1999 Jun 15;18(12):3380-91
pubmed: 10369678
Nat Rev Genet. 2004 Dec;5(12):911-22
pubmed: 15573123
Oncogene. 2006 Oct 30;25(51):6749-57
pubmed: 17072326
Cell Death Dis. 2019 Nov 26;10(12):893
pubmed: 31772150
J Immunol. 2011 Jan 15;186(2):649-56
pubmed: 21209287
Development. 1993 Jan;117(1):29-43
pubmed: 8223253
Genes Dev. 1998 Feb 15;12(4):557-70
pubmed: 9472024
Cell Death Dis. 2018 Nov 15;9(12):1140
pubmed: 30442927
Science. 2014 Dec 5;346(6214):1258236
pubmed: 25477468
Oncotarget. 2015 Nov 17;6(36):38552-65
pubmed: 26462024
Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93
pubmed: 9435236
Apoptosis. 2017 Apr;22(4):479-490
pubmed: 28150056
Science. 2000 May 5;288(5467):870-4
pubmed: 10797012
J Biol Chem. 2011 Feb 11;286(6):4517-24
pubmed: 21131352
PLoS Genet. 2015 Oct 23;11(10):e1005595
pubmed: 26496642
EMBO J. 2002 Jun 17;21(12):3009-18
pubmed: 12065414
Development. 2002 Jan;129(2):339-46
pubmed: 11807027
EMBO J. 2007 Jan 24;26(2):380-90
pubmed: 17183370
Genes Dev. 2001 Sep 15;15(18):2321-42
pubmed: 11562344
Cell. 1995 Nov 3;83(3):451-61
pubmed: 8521475
Cells. 2019 Jun 12;8(6):
pubmed: 31212769
Cell. 1988 Jan 29;52(2):269-79
pubmed: 2449285
Development. 2005 Sep;132(17):3935-46
pubmed: 16079158
Cell Death Differ. 2017 Aug;24(8):1422-1430
pubmed: 28524858
Curr Biol. 2002 Jul 23;12(14):1263-8
pubmed: 12176339
Curr Biol. 2019 Sep 9;29(17):2790-2800.e4
pubmed: 31402304
Cell Prolif. 2019 May;52(3):e12593
pubmed: 30847993
Biol Chem. 2014 Feb;395(2):203-30
pubmed: 24127541
Cell Death Differ. 2008 Jul;15(7):1132-8
pubmed: 18437164
Biochem J. 2003 Mar 1;370(Pt 2):661-9
pubmed: 12443531
Genes Dev. 1999 Apr 1;13(7):792-7
pubmed: 10197979
Annu Rev Cell Dev Biol. 2006;22:623-50
pubmed: 16842034
Cell Death Dis. 2015 May 07;6:e1737
pubmed: 25950467
Dev Cell. 2018 Sep 24;46(6):706-719.e5
pubmed: 30146479
Nat Commun. 2018 Apr 18;9(1):1541
pubmed: 29670104
Cell Res. 2012 Feb;22(2):425-31
pubmed: 21844890
Sci Rep. 2017 Jul 12;7(1):5183
pubmed: 28701716
Elife. 2018 Nov 19;7:
pubmed: 30451683
Curr Opin Cell Biol. 1998 Apr;10(2):205-19
pubmed: 9561845
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20054-9
pubmed: 22123964
Nat Immunol. 2002 Feb;3(2):121-6
pubmed: 11812988
Annu Rev Biochem. 2016 Jun 2;85:743-63
pubmed: 26865533
Development. 1990 Sep;110(1):105-14
pubmed: 2081453
Nat Cell Biol. 2002 Jun;4(6):445-50
pubmed: 12021771
Oncogene. 2008 Oct 20;27(48):6245-51
pubmed: 18931691
Open Biol. 2015 Jul;5(7):140171
pubmed: 26202785
Nature. 1997 Jul 24;388(6640):394-7
pubmed: 9237759
Science. 1998 Aug 28;281(5381):1312-6
pubmed: 9721091
Cell. 2000 Oct 13;103(2):239-52
pubmed: 11057897
Curr Opin Genet Dev. 2002 Feb;12(1):14-21
pubmed: 11790549
Dev Cell. 2008 Jan;14(1):76-85
pubmed: 18194654
Curr Opin Immunol. 2001 Feb;13(1):104-8
pubmed: 11154925
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5691-6
pubmed: 9159134
Sci Rep. 2016 Mar 03;6:22348
pubmed: 26936649
Science. 2001 Feb 23;291(5508):1544-7
pubmed: 11222859
Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28
pubmed: 11076791