Electrochemical methods to enhance osseointegrated prostheses.

Biofilms Electrical stimulation Electrochemical impedance spectroscopy Implant associated infection Osseointegration Osteogenesis

Journal

Biomedical engineering letters
ISSN: 2093-985X
Titre abrégé: Biomed Eng Lett
Pays: Germany
ID NLM: 101567784

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 05 05 2019
revised: 11 10 2019
accepted: 20 10 2019
entrez: 17 3 2020
pubmed: 17 3 2020
medline: 17 3 2020
Statut: epublish

Résumé

Osseointegrated (OI) prosthetic limbs have been shown to provide an advantageous treatment option for amputees. In order for the OI prosthesis to be successful, the titanium implant must rapidly achieve and maintain proper integration with the bone tissue and remain free of infection. Electrochemical methods can be utilized to control and/or monitor the interfacial microenvironment where the titanium implant interacts with the biological system (host bone tissue or bacteria). This review will summarize the current understanding of how electrochemical modalities can influence bone tissue and bacteria with specific emphasis on applications where the metallic prosthesis itself can be utilized directly as a stimulating electrode for enhanced osseointegration and infection control. In addition, a summary of electrochemical impedance sensing techniques that could be used to potentially assess osseointegration and infection status of the metallic prosthesis is presented.

Identifiants

pubmed: 32175128
doi: 10.1007/s13534-019-00134-8
pii: 134
pmc: PMC7046908
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

17-41

Informations de copyright

© Korean Society of Medical and Biological Engineering 2019.

Déclaration de conflit d'intérêts

Conflict of interestThe authors declare that they have no conflict of interest.

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Auteurs

Mark T Ehrensberger (MT)

1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.
2Department of Orthopaedics, University at Buffalo, Buffalo, NY USA.

Caelen M Clark (CM)

1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.

Mary K Canty (MK)

1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.
3Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY USA.

Eric P McDermott (EP)

1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.

Classifications MeSH