Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors.
anorexia
citrus unshiu peel
kampo medicine
ninjinyoeito
orexin 1 receptor
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
11
2019
accepted:
10
01
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
17
3
2020
Statut:
epublish
Résumé
Cancer cachexia is highly prevalent in patients with progressive cancer and is characterized by decreased food consumption, and body weight. Japanese herbal medicine Ninjinyoeito (NYT), composed of 12 herbal crude drugs, is prescribed in Asian countries to improve several symptoms such as anorexia and fatigue, which are commonly observed in patients with cancer cachexia. However, the action mechanisms of NYT in improving anorexia or fatigue in patients with cancer are not clear. Therefore, in the present study, we examined the effects of NYT on the activities of several G-protein-coupled receptors (GPCRs), which activate hyperphagia signaling in the central nervous system, using an
Identifiants
pubmed: 32175325
doi: 10.3389/fnut.2020.00005
pmc: PMC7056666
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5Informations de copyright
Copyright © 2020 Miyano, Ohshima, Suzuki, Furuya, Yoshida, Nonaka, Higami, Yoshizawa, Fujii and Uezono.
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