Renovascular hypertension from the BCR-ABL tyrosine kinase inhibitor ponatinib.
Drug Resistance, Neoplasm
/ drug effects
Fusion Proteins, bcr-abl
Humans
Hypertension, Renovascular
/ chemically induced
Imidazoles
/ adverse effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Protein Kinase Inhibitors
/ adverse effects
Pyridazines
/ adverse effects
Vascular Endothelial Growth Factor A
BCR-ABL mutation
drug-induced hypertension
hypertension
renovascular hypertension
tyrosine kinase inhibitors
Journal
Journal of clinical hypertension (Greenwich, Conn.)
ISSN: 1751-7176
Titre abrégé: J Clin Hypertens (Greenwich)
Pays: United States
ID NLM: 100888554
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
13
01
2020
revised:
13
02
2020
accepted:
24
02
2020
pubmed:
17
3
2020
medline:
20
5
2021
entrez:
17
3
2020
Statut:
ppublish
Résumé
Drug-induced hypertension is one of the commonest causes of secondary hypertension. In the last few years, secondary hypertension due to tyrosine kinase inhibitors, from the vascular endothelial growth factor class, has been recognized to be an important cause of hypertension, as well as proteinuria, and occasionally kidney dysfunction in some cases. Less well-recognized is that BCR-ABL tyrosine kinase inhibitors also have adverse vascular effects. These manifest as vascular stenoses in large vessels, which may sometimes cause renal artery stenosis and subsequent hypertension. We describe a case report which presented as classical bilateral renal artery stenosis, and responded to revascularization. Increased awareness of these effects, as well as research into the pathogenesis, may provide more insight into vascular biology.
Identifiants
pubmed: 32175644
doi: 10.1111/jch.13843
pmc: PMC8029973
doi:
Substances chimiques
Imidazoles
0
Protein Kinase Inhibitors
0
Pyridazines
0
Vascular Endothelial Growth Factor A
0
ponatinib
4340891KFS
Fusion Proteins, bcr-abl
EC 2.7.10.2
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
678-682Informations de copyright
© 2020 Wiley Periodicals, Inc.
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