Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Animals
Antineoplastic Agents
/ pharmacology
Bortezomib
/ pharmacology
Carcinogenesis
/ genetics
Cell Cycle
/ genetics
Cell Line, Tumor
Cell Survival
/ drug effects
Female
Gene Expression Regulation, Neoplastic
Gene Knockout Techniques
Humans
Mice
Mice, SCID
Multiple Myeloma
/ genetics
Nucleotidyltransferases
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt
/ antagonists & inhibitors
Pyrazoles
/ pharmacology
Signal Transduction
Thiophenes
/ pharmacology
FAM46C
PI3K-Akt
multiple myeloma
tumor suppressor
tumorigenesis
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
10
11
2019
revised:
21
02
2020
accepted:
06
03
2020
pubmed:
17
3
2020
medline:
2
6
2020
entrez:
17
3
2020
Statut:
ppublish
Résumé
Loss of heterozygosity or mutation of the family with sequence similarity 46, member C (FAM46C) gene on chromosome band 1p12 is associated with shorter overall survival of patients with multiple myeloma (MM). In this study, using human MM cell lines (KMS-11, OCI-My5, and ANBL-6), we generated FAM46C
Identifiants
pubmed: 32176823
doi: 10.1111/cas.14386
pmc: PMC7226186
doi:
Substances chimiques
Antineoplastic Agents
0
Pyrazoles
0
Thiophenes
0
Bortezomib
69G8BD63PP
afuresertib
8739X25QI3
PIK3R3 protein, human
EC 2.7.1.137
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Nucleotidyltransferases
EC 2.7.7.-
TENT5C protein, human
EC 2.7.7.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1663-1675Subventions
Organisme : Bristol-Myers Squibb
Organisme : Japanese Society of Myeloma Research Award
Organisme : Nagao Memorial Fund
Organisme : The Japanese Society of Hematology Research Grant
Organisme : YOKOYAMA Foundation for Clinical Pharmacology
ID : YRY-1709
Organisme : Celgene
Organisme : Japan Society for the Promotion of Science
ID : 18K08342
Organisme : Japan Society for the Promotion of Science
ID : 19K08825
Informations de copyright
© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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