Tumor Cell Invasion in Glioblastoma.
genetic program
glioblastoma
glioma
invasion
microenvironment
migration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
received:
13
02
2020
revised:
02
03
2020
accepted:
09
03
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches.
Identifiants
pubmed: 32178267
pii: ijms21061932
doi: 10.3390/ijms21061932
pmc: PMC7139341
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Neurosurg. 2005 Apr;102(4):738-44
pubmed: 15871520
Arch Neurol. 2012 Apr;69(4):523-6
pubmed: 22158715
J Immunol. 2012 Jul 1;189(1):444-53
pubmed: 22664874
Oncotarget. 2014 Oct 15;5(19):9382-95
pubmed: 25237832
Nat Protoc. 2006;1(3):1223-6
pubmed: 17406405
Nat Rev Mol Cell Biol. 2009 May;10(5):332-43
pubmed: 19373241
Oncotarget. 2017 Jan 31;8(5):8250-8263
pubmed: 28030813
Cell Stem Cell. 2014 Mar 6;14(3):357-69
pubmed: 24607407
Biochim Biophys Acta. 2014 Aug;1840(8):2386-95
pubmed: 24721714
Cancer Res. 2016 Apr 15;76(8):2465-77
pubmed: 26896279
J Cell Biol. 2011 Jan 24;192(2):209-18
pubmed: 21263025
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cell. 2017 Feb 9;168(4):613-628
pubmed: 28187284
Front Pharmacol. 2016 Dec 07;7:477
pubmed: 28003805
J Neurosci. 1999 Jul 15;19(14):5942-54
pubmed: 10407033
Nucleic Acids Res. 2006;34(21):e143
pubmed: 17071717
Nat Commun. 2019 Dec 13;10(1):5704
pubmed: 31836713
Nat Rev Genet. 2016 Mar;17(3):175-88
pubmed: 26806412
EBioMedicine. 2018 Nov;37:56-67
pubmed: 30314897
J Cell Biochem. 2019 Aug;120(8):12489-12499
pubmed: 30816613
J Clin Invest. 2009 Jun;119(6):1420-8
pubmed: 19487818
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5
pubmed: 19617536
Front Oncol. 2019 May 21;9:374
pubmed: 31165039
Cancer Cell. 2010 May 18;17(5):510-22
pubmed: 20399149
Nat Rev Cancer. 2003 May;3(5):362-74
pubmed: 12724734
Cancer Cell. 2010 Jan 19;17(1):98-110
pubmed: 20129251
Oncotarget. 2015 Oct 6;6(30):29675-93
pubmed: 26377974
Int J Oncol. 2010 Nov;37(5):1121-31
pubmed: 20878060
Cancer Cell. 2009 Jun 2;15(6):501-13
pubmed: 19477429
Neoplasia. 2010 Jun;12(6):453-63
pubmed: 20563248
Sci Rep. 2019 Feb 14;9(1):2054
pubmed: 30765850
Mol Cell. 2017 Feb 16;65(4):631-643.e4
pubmed: 28212749
Science. 2018 May 11;360(6389):660-663
pubmed: 29748285
Oncotarget. 2010 Dec;1(8):700-9
pubmed: 21321379
Curr Opin Cell Biol. 2010 Oct;22(5):690-6
pubmed: 20829016
Nature. 2019 Sep;573(7775):532-538
pubmed: 31534219
Nat Genet. 2016 Jul;48(7):768-76
pubmed: 27270107
Mol Med. 2012 May 09;18:519-27
pubmed: 22294205
Cell Rep. 2019 Feb 12;26(7):1893-1905.e7
pubmed: 30759398
Cancers (Basel). 2011 Feb 21;3(1):716-29
pubmed: 21643534
Neuro Oncol. 2017 Jan;19(1):128-137
pubmed: 27502248
Cancer Res. 2016 Oct 1;76(19):5845-5856
pubmed: 27488520
Cancer Res. 1995 Nov 15;55(22):5187-90
pubmed: 7585571
Cancer Res. 2008 Jul 15;68(14):5706-15
pubmed: 18632623
Oncol Lett. 2019 Jul;18(1):359-367
pubmed: 31289507
Cell. 2013 Dec 19;155(7):1639-51
pubmed: 24332913
Trends Cell Biol. 2015 Apr;25(4):198-213
pubmed: 25540894
Nature. 2010 Jan 21;463(7279):318-25
pubmed: 20032975
Adv Drug Deliv Rev. 2014 Dec 15;79-80:172-83
pubmed: 25174308
Cancer Res. 2003 Sep 15;63(18):5821-8
pubmed: 14522905
Breast Cancer Res. 2020 Jan 13;22(1):6
pubmed: 31931856
Genes Dev. 2003 Jan 1;17(1):7-30
pubmed: 12514095
Neurosurg Focus. 2006 Apr 15;20(4):E5
pubmed: 16709036
Cancer Cell. 2017 Jul 10;32(1):42-56.e6
pubmed: 28697342
Am J Transl Res. 2015 Mar 15;7(3):607-15
pubmed: 26045899
Neuro Oncol. 2009 Aug;11(4):368-80
pubmed: 19033423
Nat Cell Biol. 2013 Apr;15(4):338-44
pubmed: 23548926
Nat Rev Mol Cell Biol. 2009 Jul;10(7):445-57
pubmed: 19546857
Cancer Cell. 2015 Sep 14;28(3):318-28
pubmed: 26373279
Nat Commun. 2019 Jul 18;10(1):3170
pubmed: 31320621
Nat Rev Genet. 2015 Dec;16(12):716-26
pubmed: 26460349
Transl Oncol. 2019 Jan;12(1):122-133
pubmed: 30292065
Biochem Soc Trans. 2019 Apr 30;47(2):625-638
pubmed: 30902924
BMC Genomics. 2008 Jan 29;9:54
pubmed: 18230158
J Neurosurg. 1990 Mar;72(3):463-75
pubmed: 2406382
Histochem Cell Biol. 2008 Oct;130(4):635-53
pubmed: 18696101
Cell. 2011 Nov 23;147(5):992-1009
pubmed: 22118458
Bioinformatics. 2002 Feb;18(2):333-4
pubmed: 11847087
Nat Cell Biol. 2012 Aug;14(8):777-83
pubmed: 22854810
J Neurooncol. 2004 Nov;70(2):217-28
pubmed: 15674479
J Cell Biochem. 2019 Sep;120(9):15527-15537
pubmed: 31062400
Nat Rev Neurosci. 2014 Jul;15(7):455-65
pubmed: 24946761
J Neurooncol. 2014 Oct;120(1):73-83
pubmed: 25064688
Cancer Cell. 2007 Jan;11(1):69-82
pubmed: 17222791
Sci Rep. 2019 Dec 12;9(1):18975
pubmed: 31831833
Br J Cancer. 2014 Mar 4;110(5):1307-15
pubmed: 24518591
Oncogene. 2018 Feb 8;37(6):777-786
pubmed: 29059154
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2595-604
pubmed: 22923691
Cell. 2007 Aug 24;130(4):601-10
pubmed: 17719539
Cancer Cell. 2018 May 14;33(5):874-889.e7
pubmed: 29681511
Cell Rep. 2017 Oct 31;21(5):1399-1410
pubmed: 29091775
Cell. 2018 Jan 11;172(1-2):205-217.e12
pubmed: 29307488
IEEE Trans Biomed Eng. 2011 Dec;58(12):3469-74
pubmed: 21947516
Lancet Oncol. 2009 May;10(5):459-66
pubmed: 19269895
Cancer Res. 2017 Oct 1;77(19):5360-5373
pubmed: 28807938
J Neurooncol. 2001 Jun;53(2):161-76
pubmed: 11716068
Br J Cancer. 2007 May 21;96(10):1560-8
pubmed: 17453002
Nature. 2004 Nov 18;432(7015):396-401
pubmed: 15549107
Int J Oncol. 2016 Dec;49(6):2359-2366
pubmed: 27840905
Mol Cancer Res. 2009 Feb;7(2):157-67
pubmed: 19208739
PLoS One. 2015 Jun 22;10(6):e0131059
pubmed: 26098895
Nat Commun. 2019 Mar 8;10(1):1146
pubmed: 30850588
J R Soc Interface. 2017 Nov;14(136):
pubmed: 29118112
Neuro Oncol. 2018 Jan 10;20(1):37-43
pubmed: 29016805
Science. 2013 Mar 29;339(6127):1567-70
pubmed: 23539597
Strahlenther Onkol. 2003 May;179(5):337-44
pubmed: 12740661
Cell Rep. 2019 Mar 19;26(12):3203-3211.e5
pubmed: 30893594
Nat Biotechnol. 2002 Apr;20(4):387-92
pubmed: 11923846
Trends Genet. 2017 Feb;33(2):155-168
pubmed: 28089370
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4009-14
pubmed: 23412337
Neuro Oncol. 2014 Sep;16(9):1229-43
pubmed: 24861878
Nature. 2015 Dec 3;528(7580):93-8
pubmed: 26536111
Science. 2014 Jun 20;344(6190):1396-401
pubmed: 24925914
Neuro Oncol. 2018 Apr 9;20(5):621-631
pubmed: 29401256
J Neurosurg. 1998 Jan;88(1):1-10
pubmed: 9420066
Cancer Res. 2018 Oct 15;78(20):5970-5979
pubmed: 30154148
J Neurosurg. 2019 Apr 26;:1-8
pubmed: 31026822
Mol Cancer. 2010 Jul 20;9:194
pubmed: 20646316
Neuron. 2011 May 26;70(4):687-702
pubmed: 21609825
Oncotarget. 2019 Mar 12;10(21):2041-2054
pubmed: 31007847
Cancer Res. 2007 May 1;67(9):4010-5
pubmed: 17483311
Carcinogenesis. 2014 Sep;35(9):2014-24
pubmed: 24717311
PLoS One. 2011;6(10):e25451
pubmed: 21998659
Cancer Cell. 2013 Sep 9;24(3):331-46
pubmed: 23993863
Nat Clin Pract Neurol. 2008 Aug;4(8):427-35
pubmed: 18628751
J Neuropathol Exp Neurol. 2016 May;75(5):429-40
pubmed: 27030742
Mol Cell. 2019 Jul 11;75(1):7-12
pubmed: 31299208
PLoS One. 2014 Nov 03;9(11):e111783
pubmed: 25365423
Cancer Res. 2009 Sep 15;69(18):7135-9
pubmed: 19738043
Nat Rev Cancer. 2011 Jul 22;11(8):573-87
pubmed: 21779009
Cancer Res. 2003 Aug 1;63(15):4315-21
pubmed: 12907597
Int J Clin Exp Pathol. 2013;6(4):546-60
pubmed: 23573302
Science. 2003 Dec 5;302(5651):1704-9
pubmed: 14657486
PLoS One. 2013 Jun 06;8(6):e66008
pubmed: 23762456
Clin Cancer Res. 2018 Dec 15;24(24):6288-6299
pubmed: 30054278
Brain Res. 2018 Dec 1;1700:199-210
pubmed: 30176243
Nat Protoc. 2006;1(5):2452-6
pubmed: 17406491
Nat Neurosci. 2007 Aug;10(8):970-9
pubmed: 17618279
Open Med (Wars). 2017 Aug 12;12:247-251
pubmed: 28828406
Sci Signal. 2015 Dec 08;8(406):ra125
pubmed: 26645582
Int J Cancer. 2012 Oct 15;131(8):1779-89
pubmed: 22287159
Sci Rep. 2017 Aug 8;7(1):7529
pubmed: 28790339
Elife. 2020 Feb 04;9:
pubmed: 32014107
Blood. 1999 Mar 1;93(5):1658-67
pubmed: 10029595
Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15550-15559
pubmed: 31235578
Cell. 2019 Aug 8;178(4):835-849.e21
pubmed: 31327527
Neuroscience. 2015 Oct 1;305:86-98
pubmed: 26254240
Nat Biotechnol. 2020 Mar;38(3):333-342
pubmed: 31932730
Oncogene. 2008 Jun 5;27(25):3587-95
pubmed: 18212741
Oncogene. 2010 Aug 26;29(34):4741-51
pubmed: 20531305
Cell Rep. 2016 Dec 13;17(11):2994-3009
pubmed: 27974212
Nat Commun. 2014 Jun 19;5:4196
pubmed: 24943270
Nat Commun. 2018 Jun 20;9(1):2419
pubmed: 29925878
Genes Dev. 2011 Dec 15;25(24):2594-609
pubmed: 22190458
Front Neurosci. 2019 Sep 20;13:966
pubmed: 31619949
Cancers (Basel). 2018 Dec 13;10(12):
pubmed: 30551687
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5248-53
pubmed: 24706837
BMC Med Genomics. 2014 Jun 02;7:30
pubmed: 24889866
Cancers (Basel). 2018 Dec 20;11(1):
pubmed: 30577488
Science. 2009 Nov 27;326(5957):1216-9
pubmed: 19965464
Cancer Res. 2008 Sep 15;68(18):7247-9
pubmed: 18794108
Cereb Cortex. 2012 Oct;22(10):2285-96
pubmed: 22095212
N Engl J Med. 2005 Aug 25;353(8):811-22
pubmed: 16120861
Neoplasia. 2015 Jan;17(1):1-15
pubmed: 25622895
Cell. 2017 Aug 24;170(5):845-859.e19
pubmed: 28823557
Dev Cell. 2013 Mar 11;24(5):447-58
pubmed: 23484852
PLoS One. 2012;7(12):e52113
pubmed: 23284888
EMBO Mol Med. 2013 Aug;5(8):1196-212
pubmed: 23818228
Genes Dev. 2008 Dec 1;22(23):3268-81
pubmed: 19056882
Proc Natl Acad Sci U S A. 2016 May 10;113(19):5394-9
pubmed: 27118839
Acta Neuropathol. 2007 Nov;114(5):443-58
pubmed: 17805551
J Neurooncol. 2004 Oct;70(1):3-15
pubmed: 15527101
PLoS One. 2010 Mar 23;5(3):e9807
pubmed: 20352103
Nat Neurosci. 2016 Jan;19(1):20-7
pubmed: 26713745
J Neurooncol. 2019 Jan;141(2):315-325
pubmed: 30460633
JAMA. 2017 Dec 19;318(23):2306-2316
pubmed: 29260225
Front Bioeng Biotechnol. 2016 Feb 12;4:12
pubmed: 26904541
Cancer Res. 2006 Jan 15;66(2):775-83
pubmed: 16424009
Br J Dermatol. 2006 May;154 Suppl 1:11-5
pubmed: 16712711
Oncol Lett. 2017 May;13(5):3882-3888
pubmed: 28529599
J Clin Invest. 2010 Jul;120(7):2516-27
pubmed: 20530873
Cancer Res. 2004 Oct 1;64(19):7011-21
pubmed: 15466194
Cell. 1995 Jan 27;80(2):293-9
pubmed: 7834749
J Neurooncol. 2018 Jan;136(1):1-11
pubmed: 29081039
Acta Neuropathol. 1999 Mar;97(3):231-9
pubmed: 10090669
Mol Biol Cell. 2008 Aug;19(8):3357-68
pubmed: 18495866
Genome Med. 2018 Jul 24;10(1):57
pubmed: 30041684
Glia. 2009 Sep;57(12):1306-15
pubmed: 19191326
Cell. 2016 Jun 30;166(1):21-45
pubmed: 27368099
Nat Rev Neurosci. 2013 Oct;14(10):722-9
pubmed: 23985834
J Neurooncol. 2006 Mar;77(1):1-7
pubmed: 16292494
J Pathol. 2011 Jul;224(3):344-54
pubmed: 21618540
PLoS One. 2013 Aug 15;8(8):e72134
pubmed: 23967279
Nat Protoc. 2006;1(3):1165-71
pubmed: 17406399
Methods Mol Biol. 2015;1346:69-83
pubmed: 26542716
Mol Cancer. 2012 May 14;11:32
pubmed: 22583806
Curr Opin Cell Biol. 2006 Oct;18(5):516-23
pubmed: 16919435
Brain Pathol. 2009 Oct;19(4):573-85
pubmed: 18662234
Cell Adh Migr. 2008 Jul-Sep;2(3):202-7
pubmed: 19262113
Methods. 2005 Oct;37(2):208-15
pubmed: 16288884
BMC Cancer. 2010 Jun 17;10:301
pubmed: 20565806
Nat Methods. 2019 Oct;16(10):987-990
pubmed: 31501547
Tumour Biol. 2016 Jan;37(1):61-9
pubmed: 26493995
J Neurosci. 2011 Nov 23;31(47):17250-9
pubmed: 22114291
Cancer Res. 2009 Sep 1;69(17):6790-8
pubmed: 19706761
J Neurooncol. 2011 Jan;101(2):319-23
pubmed: 21052776
Front Oncol. 2017 Jun 16;7:120
pubmed: 28670569
J Neurosci. 2011 Mar 30;31(13):4858-67
pubmed: 21451024
Nat Cell Biol. 2020 Jan;22(1):38-48
pubmed: 31871321
Histol Histopathol. 2015 Nov;30(11):1255-69
pubmed: 25892148