Metabolic Syndrome is Associated with Oxidative Stress and Proinflammatory State.
PBMCs
cytokine
inflammation
metabolic syndrome
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
received:
07
02
2020
revised:
05
03
2020
accepted:
10
03
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
18
3
2020
Statut:
epublish
Résumé
Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells.
Identifiants
pubmed: 32178436
pii: antiox9030236
doi: 10.3390/antiox9030236
pmc: PMC7139344
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : Projects PI14/00636 and PI17/01827, Red Predimed-RETIC RD06/0045/1004, and CIBEROBN CB12/03/30038
Organisme : European Cooperation in Science and Technology
ID : CA16112
Organisme : Balearic Islands Gov
ID : 35/2011 and 23/2012
Organisme : Fundació La Marató TV3
ID : 201630.10
Organisme : IDISBA
ID : FOLIUM, PRIMUS, SYNERGIA, and LIBERI
Organisme : European Regional Development Fund
ID : nc
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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