Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants.
cathepsin
chronic obstructive pulmonary disease (COPD)
cysteine
cysteine protease
lung inflammation
oxidation
proteolysis
thiol
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
received:
20
02
2020
revised:
10
03
2020
accepted:
10
03
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Besides their primary involvement in the recycling and degradation of proteins in endo-lysosomal compartments and also in specialized biological functions, cysteine cathepsins are pivotal proteolytic contributors of various deleterious diseases. While the molecular mechanisms of regulation via their natural inhibitors have been exhaustively studied, less is currently known about how their enzymatic activity is modulated during the redox imbalance associated with oxidative stress and their exposure resistance to oxidants. More specifically, there is only patchy information on the regulation of lung cysteine cathepsins, while the respiratory system is directly exposed to countless exogenous oxidants contained in dust, tobacco, combustion fumes, and industrial or domestic particles. Papain-like enzymes (clan CA, family C1, subfamily C1A) encompass a conserved catalytic thiolate-imidazolium pair (Cys25-His159) in their active site. Although the sulfhydryl group (with a low acidic pKa) is a potent nucleophile highly susceptible to chemical modifications, some cysteine cathepsins reveal an unanticipated resistance to oxidative stress. Besides an introductory chapter and peculiar attention to lung cysteine cathepsins, the purpose of this review is to afford a concise update of the current knowledge on molecular mechanisms associated with the regulation of cysteine cathepsins by redox balance and by oxidants (e.g., Michael acceptors, reactive oxygen, and nitrogen species).
Identifiants
pubmed: 32178437
pii: ijms21061944
doi: 10.3390/ijms21061944
pmc: PMC7139492
pii:
doi:
Substances chimiques
Oxidants
0
Cathepsins
EC 3.4.-
Cysteine Endopeptidases
EC 3.4.22.-
Papain
EC 3.4.22.2
Cysteine
K848JZ4886
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Infect Dis. 2004 Oct 1;190(7):1245-53
pubmed: 15346334
ACS Chem Biol. 2015 Aug 21;10(8):1825-30
pubmed: 26039147
Protein Sci. 2002 Apr;11(4):831-40
pubmed: 11910026
EMBO J. 1991 Sep;10(9):2321-30
pubmed: 1868826
Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L709-17
pubmed: 15608151
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):444-8
pubmed: 1346070
Chem Rev. 2002 Dec;102(12):4459-88
pubmed: 12475197
Eur J Biochem. 1999 Aug;263(3):717-25
pubmed: 10469135
Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L625-L638
pubmed: 31553637
Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1666-80
pubmed: 9603153
Pediatr Pulmonol. 2010 Sep;45(9):860-8
pubmed: 20632407
Antioxid Redox Signal. 2013 Jan 1;18(1):94-127
pubmed: 22746677
J Mol Biol. 2002 Sep 20;322(3):559-68
pubmed: 12225749
Exp Cell Res. 2018 Jan 1;362(1):180-187
pubmed: 29196167
Biomed Biochim Acta. 1986;45(11-12):1363-74
pubmed: 3555466
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S155-9
pubmed: 7952652
J Biol Chem. 2014 Jun 6;289(23):16239-51
pubmed: 24790080
J Biol Chem. 2005 Feb 4;280(5):3125-8
pubmed: 15590625
PLoS One. 2011;6(11):e27197
pubmed: 22073285
Eur Respir J. 2004 Apr;23(4):620-8
pubmed: 15083765
Blood. 2011 Oct 13;118(15):4199-208
pubmed: 21846901
Biochim Biophys Acta. 2012 Jan;1824(1):68-88
pubmed: 22024571
Aging Cell. 2019 Feb;18(1):e12856
pubmed: 30575263
Antioxid Redox Signal. 2000 Winter;2(4):851-78
pubmed: 11213489
Environ Health Perspect. 2000 Aug;108 Suppl 4:675-84
pubmed: 10931786
Expert Opin Drug Discov. 2016;11(5):457-72
pubmed: 27001692
Biochem J. 1992 Jul 15;285 ( Pt 2):495-502
pubmed: 1637341
Biol Chem. 2015 Aug;396(8):867-82
pubmed: 25872877
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165448
pubmed: 30954558
Annu Rev Physiol. 1997;59:63-88
pubmed: 9074757
Bioorg Med Chem Lett. 2009 Jan 15;19(2):356-9
pubmed: 19081252
Can J Biochem. 1975 Mar;53(3):298-307
pubmed: 1125817
Mol Biosyst. 2008 Jun;4(6):521-31
pubmed: 18493649
Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):177-84
pubmed: 9484981
J Immunol. 2001 Aug 15;167(4):2172-8
pubmed: 11490002
Bioconjug Chem. 2007 Nov-Dec;18(6):2004-17
pubmed: 18030992
Respir Res. 2018 Jan 08;19(1):6
pubmed: 29310632
Nat Rev Drug Discov. 2006 Sep;5(9):785-99
pubmed: 16955069
Biol Chem. 2008 Aug;389(8):1123-6
pubmed: 18979635
Eur Respir Rev. 2018 Jan 24;27(147):
pubmed: 29367408
Chem Commun (Camb). 2012 Apr 28;48(34):4091-3
pubmed: 22430672
Allergy Asthma Immunol Res. 2018 Sep;10(5):428-447
pubmed: 30088364
Biochim Biophys Acta Proteins Proteom. 2020 Feb;1868(2):140318
pubmed: 31740411
FEBS Lett. 2008 Apr 16;582(9):1307-12
pubmed: 18343226
Radiat Res. 1977 Mar;69(3):434-41
pubmed: 847095
J Immunol. 2003 Jul 15;171(2):931-7
pubmed: 12847264
Free Radic Biol Med. 2006 May 1;40(9):1539-48
pubmed: 16632114
Acta Biochim Pol. 2004;51(4):861-73
pubmed: 15625558
N Engl J Med. 1994 Nov 10;331(19):1286-92
pubmed: 7935686
Free Radic Biol Med. 2007 Oct 15;43(8):1099-108
pubmed: 17854705
J Biol Chem. 2007 Jun 1;282(22):16492-501
pubmed: 17426030
Biochem J. 2016 Apr 1;473(7):805-25
pubmed: 27026395
BMC Biochem. 2009 Sep 22;10:23
pubmed: 19772638
Biochimie. 2008 Feb;90(2):208-26
pubmed: 17935853
J Immunol. 2007 Feb 1;178(3):1948-59
pubmed: 17237446
Biochem Biophys Res Commun. 2005 May 27;331(1):215-23
pubmed: 15845381
Antioxid Redox Signal. 2002 Aug;4(4):681-91
pubmed: 12230881
Free Radic Biol Med. 2014 Jun;71:49-60
pubmed: 24657741
J Mol Biol. 1989 Mar 5;206(1):101-18
pubmed: 2539481
Methods Enzymol. 2002;348:146-56
pubmed: 11885268
Thorax. 2002 Nov;57(11):926-9
pubmed: 12403872
Neural Regen Res. 2020 Jan;15(1):25-29
pubmed: 31535638
J Clin Invest. 1994 Oct;94(4):1506-12
pubmed: 7929826
J Cyst Fibros. 2002 Mar;1(1):13-29
pubmed: 15463806
Mol Cell. 2004 Apr 23;14(2):207-19
pubmed: 15099520
Am J Respir Cell Mol Biol. 2003 Jan;28(1):69-79
pubmed: 12495934
Redox Biol. 2014 Jun 13;2:803-13
pubmed: 25009782
Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):681-9
pubmed: 16677111
Chem Biol. 2003 Aug;10(8):677-93
pubmed: 12954327
J Clin Invest. 2000 Nov;106(9):1081-93
pubmed: 11067861
ACS Chem Biol. 2019 Apr 19;14(4):594-598
pubmed: 30893551
PLoS One. 2011;6(9):e25577
pubmed: 21980493
Curr Opin Chem Biol. 2008 Dec;12(6):746-54
pubmed: 18804173
Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):275-82
pubmed: 12588771
J Am Chem Soc. 2014 Apr 30;136(17):6167-70
pubmed: 24724926
Free Radic Biol Med. 2006 Jul 1;41(1):120-31
pubmed: 16781460
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3307-3318
pubmed: 31980525
iScience. 2019 Sep 27;19:607-622
pubmed: 31446224
J Biol Chem. 1965 Jan;240:201-8
pubmed: 14253414
Am J Respir Crit Care Med. 1999 Feb;159(2):473-9
pubmed: 9927360
Biochim Biophys Acta. 2012 Jan;1824(1):22-33
pubmed: 21914490
Biochemistry. 1999 Oct 12;38(41):13574-83
pubmed: 10521264
Annu Rev Physiol. 2009;71:489-507
pubmed: 19575684
J Leukoc Biol. 2007 May;81(5):1213-23
pubmed: 17264306
Free Radic Biol Med. 2018 Sep;125:53-61
pubmed: 29578071
Chem Res Toxicol. 2009 Apr;22(4):708-16
pubmed: 19231900
Eur Respir J. 2017 Feb 8;49(2):
pubmed: 28179435
Biochemistry. 1997 Dec 2;36(48):15013-8
pubmed: 9398227
Eur Respir J. 2019 Mar 28;53(3):
pubmed: 30655278
Atherosclerosis. 2003 Aug;169(2):215-24
pubmed: 12921972
Thorax. 1996 Apr;51(4):348-50
pubmed: 8733482
Biol Chem. 2015 Feb;396(2):111-30
pubmed: 25178906
Nature. 2003 Oct 30;425(6961):980-4
pubmed: 14586471
Biochemistry. 2015 May 5;54(17):2785-98
pubmed: 25884905
Biochemistry. 1999 Sep 28;38(39):12648-54
pubmed: 10504234
J Immunol. 2014 Jun 1;192(11):4989-5001
pubmed: 24778444
Pflugers Arch. 2001;442(6 Suppl 1):R204-6
pubmed: 11678341
J Biol Chem. 2008 Nov 7;283(45):30433-7
pubmed: 18650443
J Biol Chem. 2004 Aug 27;279(35):36761-70
pubmed: 15192101
Am J Pathol. 2004 Jun;164(6):2203-16
pubmed: 15161653
Matrix Biol. 2018 Aug;68-69:382-403
pubmed: 29518524
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10496-501
pubmed: 20498052
Biochem J. 2002 May 1;363(Pt 3):417-29
pubmed: 11964142
Curr Protein Pept Sci. 2001 Jun;2(2):137-53
pubmed: 12370021
Methods Enzymol. 1994;244:486-500
pubmed: 7845227
Trends Pharmacol Sci. 2017 Oct;38(10):873-898
pubmed: 28668224
PLoS One. 2016 Apr 27;11(4):e0153336
pubmed: 27119365
Biochem Pharmacol. 2002 Sep;64(5-6):1049-56
pubmed: 12213604
Biochem Biophys Res Commun. 2003 Jan 3;300(1):1-4
pubmed: 12480511
Nat Struct Biol. 1998 Apr;5(4):247-9
pubmed: 9546208
Exp Eye Res. 2010 Feb;90(2):261-6
pubmed: 19895809
Chem Commun (Camb). 2011 Aug 28;47(32):9203-5
pubmed: 21738918
J Biol Chem. 2019 Dec 20;294(51):19683-19708
pubmed: 31672919
Nat Rev Drug Discov. 2017 Nov;16(11):755-772
pubmed: 28983101
J Biol Chem. 1991 Aug 5;266(22):14519-25
pubmed: 1860858
Biochim Biophys Acta. 2001 Feb 9;1545(1-2):357-66
pubmed: 11342060
Methods Enzymol. 1999;300:389-95
pubmed: 9919539
Free Radic Biol Med. 2015 Mar;80:148-57
pubmed: 25433365
Biol Chem. 2002 Jul-Aug;383(7-8):1199-204
pubmed: 12437106
FEBS Lett. 2001 Jul 6;500(3):114-8
pubmed: 11445067
Cells. 2019 Mar 20;8(3):
pubmed: 30897858
Biochem J. 2006 Sep 1;398(2):197-206
pubmed: 16671891
Nat Rev Immunol. 2003 Jun;3(6):472-82
pubmed: 12776207
Am J Respir Cell Mol Biol. 2002 Jun;26(6):659-70
pubmed: 12034564
Biol Chem. 2006 Aug;387(8):1017-21
pubmed: 16895470
Biochimie. 2008 Feb;90(2):194-207
pubmed: 17825974
Neurochem Res. 2007 Sep;32(9):1499-510
pubmed: 17440810
PLoS One. 2011;6(10):e26247
pubmed: 22022579
Biochim Biophys Acta. 2006 Mar;1762(3):351-6
pubmed: 16303289
Mol Cell Proteomics. 2007 Sep;6(9):1473-84
pubmed: 17569890
Biochem Mol Biol Int. 1998 Oct;46(2):425-8
pubmed: 9801811
Free Radic Biol Med. 2008 Sep 15;45(6):749-55
pubmed: 18572022
Curr Opin Chem Biol. 2011 Feb;15(1):88-102
pubmed: 21130680
J Biol Chem. 2001 Sep 7;276(36):33345-52
pubmed: 11435427
Biochim Biophys Acta Proteins Proteom. 2020 Apr;1868(4):140360
pubmed: 31926332
Am J Respir Crit Care Med. 1999 Oct;160(4):1274-82
pubmed: 10508819
Mol Immunol. 2009 Mar;46(6):1100-8
pubmed: 19095306
Free Radic Biol Med. 2007 Jul 1;43(1):100-10
pubmed: 17561098
J Biol Chem. 2000 Jul 7;275(27):20467-73
pubmed: 10779505
Pharmacol Ther. 2018 Oct;190:202-236
pubmed: 29842917
Nat Chem Biol. 2011 Dec 11;8(1):57-64
pubmed: 22158416
EMBO J. 2001 Dec 3;20(23):6570-82
pubmed: 11726493
Arch Biochem Biophys. 2007 May 15;461(2):151-8
pubmed: 17459324
J Signal Transduct. 2010;2010:375345
pubmed: 21637353
Nucleic Acids Res. 2009 Jan;37(Database issue):D239-43
pubmed: 18776217
Respir Res. 2005 Jul 27;6:84
pubmed: 16045809
Respir Res. 2011 May 31;12:72
pubmed: 21627832
Cell. 1994 Sep 23;78(6):931-6
pubmed: 7923362
Arterioscler Thromb. 1993 Jun;13(6):791-9
pubmed: 8388713
Int J Biochem Cell Biol. 2013 Aug;45(8):1701-9
pubmed: 23707200
Bioconjug Chem. 2005 Nov-Dec;16(6):1624-8
pubmed: 16287263
EMBO J. 2012 Feb 15;31(4):932-44
pubmed: 22157818
J Biol Chem. 1986 Nov 5;261(31):14748-51
pubmed: 3490478
Free Radic Biol Med. 2014 May;70:265-77
pubmed: 24456905
Free Radic Biol Med. 2017 Jul;108:819-831
pubmed: 28478025
Methods Enzymol. 1994;244:461-86
pubmed: 7845226
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17982-7
pubmed: 15604151
J Exp Med. 2000 Dec 4;192(11):1587-600
pubmed: 11104801
Chem Soc Rev. 2018 Jan 2;47(1):231-268
pubmed: 29242887
Free Radic Biol Med. 2010 Apr 15;48(8):1071-8
pubmed: 20109544
Free Radic Biol Med. 2005 Apr 15;38(8):1102-11
pubmed: 15780768
Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):930-9
pubmed: 15998248
J Biol Chem. 1963 Jan;238:165-71
pubmed: 13976329
Free Radic Biol Med. 1997;23(2):215-25
pubmed: 9199883
J Exp Med. 2000 Apr 3;191(7):1177-86
pubmed: 10748235
Nucleic Acids Res. 2018 Jan 4;46(D1):D624-D632
pubmed: 29145643
Free Radic Biol Med. 2020 Feb 19;150:53-65
pubmed: 32084513
Chem Rev. 1997 Feb 5;97(1):133-172
pubmed: 11848867
ACS Chem Biol. 2009 Sep 18;4(9):783-99
pubmed: 19645509
Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28
pubmed: 11076791
Redox Rep. 2001;6(6):343-9
pubmed: 11865974
Am J Respir Crit Care Med. 2004 Sep 1;170(5):477-84
pubmed: 15151919
Curr Opin Allergy Clin Immunol. 2001 Jun;1(3):217-24
pubmed: 11964692
Annu Rev Pharmacol Toxicol. 2004;44:325-47
pubmed: 14744249