First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA.
Journal
Lancet (London, England)
ISSN: 1474-547X
Titre abrégé: Lancet
Pays: England
ID NLM: 2985213R
Informations de publication
Date de publication:
04 04 2020
04 04 2020
Historique:
received:
02
03
2020
revised:
06
03
2020
accepted:
06
03
2020
pubmed:
18
3
2020
medline:
10
4
2020
entrez:
18
3
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA. Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient's symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested. Patient 1-a woman in her 60s-returned from China in mid-January, 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2. Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected. None.
Sections du résumé
BACKGROUND
Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA.
METHODS
Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient's symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested.
FINDINGS
Patient 1-a woman in her 60s-returned from China in mid-January, 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2.
INTERPRETATION
Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected.
FUNDING
None.
Identifiants
pubmed: 32178768
pii: S0140-6736(20)30607-3
doi: 10.1016/S0140-6736(20)30607-3
pmc: PMC7158585
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1137-1144Investigateurs
Sarah Brister
(S)
Kristin Goldesberry
(K)
Stacey Hoferka
(S)
Dejan Jovanov
(D)
Dawn Nims
(D)
Lori Saathoff-Huber
(L)
Chantel Hoskin Snelling
(C)
Hira Adil
(H)
Raabiah Ali
(R)
Elaina Andreychak
(E)
Kelley Bemis
(K)
Mabel Frias
(M)
Pearl Quartey-Kumapley
(P)
Kristin Baskerville
(K)
Elizabeth Murphy
(E)
Emily Murskyj
(E)
Zach Noffsinger
(Z)
Janice Vercillo
(J)
Apryll Elliott
(A)
Uche S Onwuta
(US)
Danielle Burck
(D)
Glen Abedi
(G)
Rachel M Burke
(RM)
Ryan Fagan
(R)
Jennifer Farrar
(J)
Alicia M Fry
(AM)
Aron J Hall
(AJ)
Amber Haynes
(A)
Connor Hoff
(C)
Shifaq Kamili
(S)
Marie E Killerby
(ME)
Lindsay Kim
(L)
Stephanie A Kujawski
(SA)
David T Kuhar
(DT)
Brian Lynch
(B)
Lakshmi Malapati
(L)
Mariel Marlow
(M)
Janná R Murray
(JR)
Brian Rha
(B)
Senthil Kumar K Sakthivel
(SKK)
Sarah E Smith-Jeffcoat
(SE)
Elizabeth Soda
(E)
Lijuan Wang
(L)
Brett L Whitaker
(BL)
Timothy M Uyeki
(TM)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Emerg Infect Dis. 2004 Feb;10(2):256-60
pubmed: 15030693
N Engl J Med. 2020 Mar 5;382(10):929-936
pubmed: 32004427
BMC Med. 2015 Sep 03;13:210
pubmed: 26336062
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
J R Soc Interface. 2020 Jul;17(168):20200144
pubmed: 32693748
N Engl J Med. 2020 Feb 27;382(9):872-874
pubmed: 31991079
Euro Surveill. 2015 Jun 25;20(25):7-13
pubmed: 26132767