Techniques for the generation of humanized mouse models for immuno-oncology.

Animals Disease Models, Animal Humans Mice Neoplasms / therapy T-Lymphocytes Tumor Microenvironment Xenograft Model Antitumor Assays
Animal model Hematopoietic progenitor cells Humanized mouse Immunotherapy Patient-derived xenograft Transplant Tumor

Journal

Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271

Informations de publication

Date de publication:
2020
Historique:
entrez: 18 3 2020
pubmed: 18 3 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Mouse models of human cancer have been used extensively to circumvent the complexity in human patients. However, murine models often inadequately recapitulate the human cancer-immune interface partly due to important differences between mouse and human immune systems. Immunodeficient mice when transplanted with CD34

Identifiants

DOI: 10.1016/bs.mie.2019.06.003 PMID: 32178826
pubmed: 32178826
pii: S0076-6879(19)30242-3
doi: 10.1016/bs.mie.2019.06.003
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

351-368

Informations de copyright

© 2020 Elsevier Inc. All rights reserved.

Auteurs

Chun I Yu (CI)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States. Electronic address: chun.yu@jax.org.

Florentina Marches (F)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.

Te-Chia Wu (TC)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.

Jan Martinek (J)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.

Karolina Palucka (K)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States. Electronic address: karolina.palucka@jax.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Techniques for the generation of humanized...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Techniques for the generation of humanized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Techniques for the generation of humanized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Techniques for the generation of humanized...
questionsmedicales.fr › Tumeurs › Techniques for the generation of humanized...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Techniques for the generation of humanized...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Techniques for the generation of humanized...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Techniques for the generation of humanized...