Preparation and Characterization of Stabilizer-Free Phytantriol-Based Water-in-Oil Internally Liquid Crystalline Emulsions.

Emulsions Fatty Alcohols Liquid Crystals Water
LUMiSizer liquid crystal phytantriol small angle X-ray scattering (SAXS) surfactant-free water-in-oil (W/O) emulsion

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
06 2020
Historique:
received: 31 10 2019
revised: 19 01 2020
accepted: 26 02 2020
pubmed: 18 3 2020
medline: 22 6 2021
entrez: 18 3 2020
Statut: ppublish

Résumé

Despite the widespread use of surfactants, there are known issues such as allergic reactions and formulation complications in their use as emulsion stabilizers. In this study, stabilizer-free water-in-oil (W/O) emulsions containing water, phytantriol, and almond oil were prepared by an ultra-turrax homogenizer, a standard laboratory equipment, and a high specialized high-shear device. Parameters such as mixing time, stirring rate, composition, order of addition of phases, and temperature were investigated to systematically optimize the preparation of the formulations through evaluating their accelerated physical stability by a centrifugal sedimentation technique. The liquid crystalline structure of the continuous phase was studied by small-angle X-ray scattering indicating a reverse hexagonal phase (H

Identifiants

DOI: 10.1016/j.xphs.2020.02.022 PMID: 32179079
pubmed: 32179079
pii: S0022-3549(20)30131-3
doi: 10.1016/j.xphs.2020.02.022
pii:
doi:

Substances chimiques

Emulsions 0
Fatty Alcohols 0
Water 059QF0KO0R
3,7,11,15-tetramethyl-1,2,3-hexadecanetriol 8LVI07A72W

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2024-2032

Informations de copyright

Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Seyedeh Parinaz Akhlaghi (SP)

Institute of Chemistry, University of Campinas (UNICAMP), PO Box 6154, 13083-970 Campinas, SP, Brazil; Department of Chemical Engineering and Applied Chemistry, Faculty of Applied Science and Engineering, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada. Electronic address: parinaz.akhlaghi@utoronto.ca.

Lia Beraldo da Silveira Balestrin (LB)

Institute of Chemistry, University of Campinas (UNICAMP), PO Box 6154, 13083-970 Campinas, SP, Brazil.

César Brinatti (C)

Institute of Chemistry, University of Campinas (UNICAMP), PO Box 6154, 13083-970 Campinas, SP, Brazil.

Franz Pirolt (F)

Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.

Watson Loh (W)

Institute of Chemistry, University of Campinas (UNICAMP), PO Box 6154, 13083-970 Campinas, SP, Brazil.

Otto Glatter (O)

Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Preparation and Characterization of...
questionsmedicales.fr › Lipides › Alcools gras › Preparation and Characterization of...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Cristaux liquides › Preparation and Characterization of...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Preparation and Characterization of...