Teicoplanin: an alternative drug for the treatment of COVID-19?
COVID-19
Drug repurposing
SARS-CoV-2
Teicoplanin
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
04
03
2020
revised:
07
03
2020
accepted:
09
03
2020
pubmed:
18
3
2020
medline:
29
4
2020
entrez:
18
3
2020
Statut:
ppublish
Résumé
In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find a therapeutic solution. Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococcal infections, previously showed efficacy to inhibit the first stage of the Middle East respiratory syndrome coronavirus (MERS-CoV) viral life cycle in human cells. This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus.
Identifiants
pubmed: 32179150
pii: S0924-8579(20)30094-7
doi: 10.1016/j.ijantimicag.2020.105944
pmc: PMC7102624
pii:
doi:
Substances chimiques
Teicoplanin
61036-62-2
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
105944Informations de copyright
Copyright © 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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