HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic.

Auto-immune disease H1N1 HLA Hypocretin Narcolepsy

Journal

Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498

Informations de publication

Date de publication:
04 Mar 2020
Historique:
received: 04 12 2019
revised: 02 03 2020
accepted: 03 03 2020
pubmed: 18 3 2020
medline: 18 3 2020
entrez: 18 3 2020
Statut: aheadofprint

Résumé

We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

Identifiants

DOI: 10.1016/j.jneuroim.2020.577210 PMID: 32179327
pubmed: 32179327
pii: S0165-5728(19)30618-6
doi: 10.1016/j.jneuroim.2020.577210
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

577210

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors confirm no conflict of interest to disclose.

Auteurs

Mink Schinkelshoek (M)

Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands; Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103, SW, Heemstede, The Netherlands. Electronic address: M.S.Schinkelshoek@lumc.nl.

Rolf Fronczek (R)

Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands; Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103, SW, Heemstede, The Netherlands.

Willem Verduijn (W)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

Geert Haasnoot (G)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

Sebastiaan Overeem (S)

Sleep Medicine Center Kempenhaeghe, PO Box 61, 5590, AB, Heeze, The Netherlands; Department of Electrical Engineering, Eindhoven University of Technology, PO Box 513, 5600, MB, Eindhoven, The Netherlands.

Claire Donjacour (C)

Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland (SEIN), Dokter Denekampweg 20, 8025, BV, Zwolle, The Netherlands.

Astrid van der Heide (A)

Department of Neurology and Neurosurgery, Brain Centre Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584, CG, Utrecht, The Netherlands.

Dave Roelen (D)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

Frans Claas (F)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

Gert Jan Lammers (GJ)

Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands; Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103, SW, Heemstede, The Netherlands.

Classifications MeSH