Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice.
Adipose Tissue, White
/ drug effects
Animals
Basal Metabolism
/ drug effects
Blood Glucose
/ analysis
Body Weight
/ drug effects
Energy Metabolism
Fatty Acids
/ administration & dosage
Fatty Liver
/ metabolism
Glucose Tolerance Test
Homeostasis
Inflammation
/ metabolism
Insulin
/ metabolism
Insulin Resistance
Lipid Metabolism
Liver
/ metabolism
Liver Cirrhosis
/ metabolism
Male
Mice
Mice, Inbred C57BL
FAHFA
Inflammation
Insulin sensitivity
Liver fibrosis
Liver steatosis
Mice
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
27
09
2019
revised:
24
01
2020
accepted:
10
02
2020
pubmed:
18
3
2020
medline:
7
4
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a new family of endogenous lipids recently discovered. Several studies reported that some FAHFAs have antidiabetic and anti-inflammatory effects. The objective of this study was to explore the impact of two FAHFAs, 9-PAHPA or 9-OAHPA, on the metabolism of mice. C57Bl/6J male mice, 6 weeks old, were divided into 3 groups of 10 mice each. One group received a control diet and the two others groups received the control diet supplemented with 9-PAHPA or 9-OAHPA for 12 weeks. Mouse weight and body composition were monitored throughout the study. Some days before euthanasia, energy expenditure, glucose tolerance and insulin sensitivity were also determined. After sacrifice, blood and organs were collected for relevant molecular, biochemical and histological analyses. Although high intake of 9-PAHPA or 9-OAHPA increased basal metabolism, it had no direct effect on body weight. Interestingly, the 9-PAHPA or 9-OAHPA intake increased insulin sensitivity but without modifying glucose tolerance. Nevertheless, 9-PAHPA intake induced a loss of glucose-stimulated insulin secretion. Surprisingly, both studied FAHFAs induced hepatic steatosis and fibrosis in some mice, which were more marked with 9-PAHPA. Finally, a slight remodeling of white adipose tissue was also observed with 9-PAHPA intake. In conclusion, the long-term high intake of 9-PAHPA or 9-OAHPA increased basal metabolism and insulin sensitivity in healthy mice. However, this effect, highly likely beneficial in a diabetic state, was accompanied by manifest liver damage in certain mice that should deserve special attention in both healthy and pathological studies.
Identifiants
pubmed: 32179409
pii: S0955-2863(19)30954-4
doi: 10.1016/j.jnutbio.2020.108361
pii:
doi:
Substances chimiques
Blood Glucose
0
Fatty Acids
0
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108361Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors confirm that this article content has no conflict of interest.