ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens
antibiotic resistance
carbapenem
metallo-β-lactamase
β-lactamase inhibitor
β-lactamases
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 05 2020
21 05 2020
Historique:
received:
03
12
2019
accepted:
05
03
2020
pubmed:
18
3
2020
medline:
22
6
2021
entrez:
18
3
2020
Statut:
epublish
Résumé
Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, there are no approved inhibitors of MBL-mediated carbapenem-resistance and treatment options for infections caused by MBL-producing Gram-negatives are limited. Here, we present ZN148, a zinc-chelating MBL-inhibitor capable of restoring the bactericidal effect of meropenem and
Identifiants
pubmed: 32179522
pii: AAC.02415-19
doi: 10.1128/AAC.02415-19
pmc: PMC7269481
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
beta-Lactamase Inhibitors
0
beta-Lactamases
EC 3.5.2.6
Meropenem
FV9J3JU8B1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Samuelsen et al.
Références
J Hyg (Lond). 1938 Nov;38(6):732-49
pubmed: 20475467
Trends Biochem Sci. 2016 Apr;41(4):338-355
pubmed: 26805042
Drugs. 2018 Jan;78(1):65-98
pubmed: 29230684
J Mol Biol. 2008 Jan 18;375(3):604-11
pubmed: 18061205
Antimicrob Agents Chemother. 2009 Jan;53(1):331-2
pubmed: 19015364
J Antimicrob Chemother. 2012 Jun;67(6):1354-8
pubmed: 22441578
Genome Announc. 2017 Jul 6;5(27):
pubmed: 28684580
Antimicrob Agents Chemother. 2017 Dec 21;62(1):
pubmed: 29038264
J Antimicrob Chemother. 2011 Mar;66(3):670-2
pubmed: 21172785
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Expert Opin Pharmacother. 2016;17(6):761-81
pubmed: 26799840
Microb Cell Fact. 2014 Mar 10;13(1):38
pubmed: 24612508
Circ Cardiovasc Genet. 2012 Oct 1;5(5):591
pubmed: 23074338
Clin Microbiol Rev. 2009 Oct;22(4):582-610
pubmed: 19822890
J Infect Dis. 2017 Feb 15;215(suppl_1):S28-S36
pubmed: 28375512
Antimicrob Agents Chemother. 2014 Aug;58(8):4826-36
pubmed: 24913158
PLoS Pathog. 2016 Jan 04;12(1):e1005359
pubmed: 26727373
Antimicrob Agents Chemother. 2018 Apr 26;62(5):
pubmed: 29530861
J Antimicrob Chemother. 2019 Apr 1;74(4):953-960
pubmed: 30590470
Trends Pharmacol Sci. 2018 Jul;39(7):635-647
pubmed: 29680579
Nat Rev Drug Discov. 2007 Jan;6(1):29-40
pubmed: 17159923
Clin Microbiol Infect. 2017 Oct;23(10):704-712
pubmed: 28893690
J Med Chem. 2017 Sep 14;60(17):7267-7283
pubmed: 28809565
Annu Rev Microbiol. 2002;56:17-38
pubmed: 12142471
J Med Chem. 2015 Nov 12;58(21):8671-82
pubmed: 26477515
J Proteome Res. 2006 Nov;5(11):3173-8
pubmed: 17081069
Antimicrob Agents Chemother. 2019 Apr 25;63(5):
pubmed: 30782985
Antimicrob Agents Chemother. 2020 Feb 21;64(3):
pubmed: 31871094
Bioorg Med Chem. 2016 Jul 1;24(13):2947-2953
pubmed: 27184103
Antimicrob Agents Chemother. 2011 Nov;55(11):4943-60
pubmed: 21859938
Bioinformatics. 2012 Jun 15;28(12):1647-9
pubmed: 22543367
ACS Infect Dis. 2018 Sep 14;4(9):1407-1422
pubmed: 30022668
Eur J Biochem. 2000 Sep;267(17):5421-6
pubmed: 10951200
Arch Toxicol. 2012 Apr;86(4):521-34
pubmed: 22071549
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Biochim Biophys Acta. 2002 Jul 3;1571(3):190-200
pubmed: 12090933
Antimicrob Agents Chemother. 2019 Apr 25;63(5):
pubmed: 30858212
Lancet Infect Dis. 2018 Mar;18(3):318-327
pubmed: 29276051
Nat Commun. 2018 Jan 30;9(1):439
pubmed: 29382822
Lancet Infect Dis. 2019 Jan;19(1):56-66
pubmed: 30409683
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54
pubmed: 27303030
Medchemcomm. 2019 Mar 8;10(4):528-537
pubmed: 31057732
Nat Rev Microbiol. 2020 May;18(5):275-285
pubmed: 31745331
Nature. 2014 Jun 26;510(7506):503-6
pubmed: 24965651
Drugs. 2019 Feb;79(3):271-289
pubmed: 30712199
Antimicrob Agents Chemother. 2018 Jul 27;62(8):
pubmed: 29760136
Future Microbiol. 2013 Aug;8(8):947-79
pubmed: 23902139
Lancet Glob Health. 2018 Sep;6(9):e969-e979
pubmed: 30103998
J Infect Chemother. 2013 Aug;19(4):549-59
pubmed: 23828655
Biochem Biophys Res Commun. 2009 Mar 27;381(1):107-11
pubmed: 19351604
ACS Infect Dis. 2018 Feb 9;4(2):135-145
pubmed: 29091730