The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease.
Adult
Aged
Discriminant Analysis
Female
Gas Chromatography-Mass Spectrometry
/ instrumentation
Humans
Margins of Excision
Mass Spectrometry
/ instrumentation
Middle Aged
Papillomaviridae
Papillomavirus Infections
/ pathology
Precancerous Conditions
/ diagnosis
Sensitivity and Specificity
Uterine Cervical Neoplasms
/ diagnosis
Uterine Cervical Dysplasia
REIMS
cervical cancer
fertility preservation
iKnife
mass spectrometry
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
31 03 2020
31 03 2020
Historique:
pubmed:
18
3
2020
medline:
15
8
2020
entrez:
18
3
2020
Statut:
ppublish
Résumé
Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also known as intelligent knife (iKnife), to discriminate between healthy, preinvasive, and invasive cervical tissue. Cervical tissue samples were collected from women with healthy, human papilloma virus (HPV) ± cervical intraepithelial neoplasia (CIN), or cervical cancer. A handheld diathermy device generated surgical aerosol, which was transferred into a mass spectrometer for subsequent chemical analysis. Combination of principal component and linear discriminant analysis and least absolute shrinkage and selection operator was employed to study the spectral differences between groups. Significance of discriminatory
Identifiants
pubmed: 32179675
pii: 1916960117
doi: 10.1073/pnas.1916960117
pmc: PMC7132269
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7338-7346Subventions
Organisme : Medical Research Council
ID : PS2857
Pays : United Kingdom
Organisme : Medical Research Council
ID : PS2897
Pays : United Kingdom
Organisme : Department of Health
ID : P83204
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A24034
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: Waters Corporation provided supplies and maintenance for the mass spectrometry equipment used. Z.T. serves as a paid consultant for Waters Corporation. J.B. is employed by Waters Corporation.
Références
Gynecol Oncol. 2013 Sep;130(3):525-9
pubmed: 23500089
Eur J Obstet Gynecol Reprod Biol. 2008 Jul;139(1):90-4
pubmed: 17980478
Surg Endosc. 2017 Mar;31(3):1361-1370
pubmed: 27501728
Dis Model Mech. 2013 Nov;6(6):1353-63
pubmed: 24203995
Lancet. 1997 Aug 23;350(9077):535-40
pubmed: 9284774
Tumour Biol. 2016 Apr;37(4):5485-92
pubmed: 26566624
Am J Obstet Gynecol. 2003 Jan;188(1):29-34
pubmed: 12548192
Cochrane Database Syst Rev. 2012 May 16;(5):CD007583
pubmed: 22592722
Radiother Oncol. 2018 Jun;127(3):404-416
pubmed: 29728273
Int J Gynaecol Obstet. 2009 May;105(2):103-4
pubmed: 19367689
Cancer. 2008 Nov 15;113(10 Suppl):2855-64
pubmed: 18980204
Br J Cancer. 2018 May;118(10):1349-1358
pubmed: 29670294
Lancet Oncol. 2011 Feb;12(2):192-200
pubmed: 20619737
J Cell Biochem. 2017 Dec;118(12):4163-4169
pubmed: 28475243
Nature. 1996 Jun 27;381(6585):800-3
pubmed: 8657285
Lancet Oncol. 2017 Dec;18(12):1665-1679
pubmed: 29126708
Breast Cancer Res. 2017 May 23;19(1):59
pubmed: 28535818
Acta Oncol. 2018 Mar;57(3):338-345
pubmed: 29140150
J Surg Oncol. 2016 Mar;113(3):304-9
pubmed: 26852901
Int J Surg Oncol. 2017;2017:2962450
pubmed: 28798874
Anal Chem. 2014 Jul 1;86(13):6555-62
pubmed: 24896667
Angew Chem Int Ed Engl. 2009;48(44):8240-2
pubmed: 19746375
Prog Chem Fats Other Lipids. 1972;13(1):1-59
pubmed: 4353425
BMC Cancer. 2018 Apr 27;18(1):485
pubmed: 29703186
Br J Cancer. 2013 Nov 26;109(11):2778-82
pubmed: 24169350
J Clin Oncol. 2000 Apr;18(8):1606-13
pubmed: 10764420
Gynecol Oncol. 2013 May;129(2):384-8
pubmed: 23395889
BMJ. 2014 Jan 14;348:f7361
pubmed: 24423603
Anal Chem. 2011 Mar 1;83(5):1632-40
pubmed: 21302917
J Gynecol Oncol. 2017 May;28(3):e34
pubmed: 28382797
Obstet Gynecol. 1993 Jun;81(6):976-82
pubmed: 8497366
Clin Chem. 2019 May;65(5):674-683
pubmed: 30770374
Gynecol Oncol. 2008 Sep;110(3):316-23
pubmed: 18635252
Anal Chem. 2011 Oct 15;83(20):7729-35
pubmed: 21916423
Int J Radiat Oncol Biol Phys. 1995 Jan 15;31(2):399-404
pubmed: 7836095
BJOG. 2016 Jan;123(1):59-66
pubmed: 26177672
Ann Oncol. 2007 Aug;18(8):1423-5
pubmed: 17693658
Int J Gynecol Cancer. 2018 May;28(4):641-655
pubmed: 29688967
J Cancer Res Ther. 2005 Jul-Sep;1(3):180-6
pubmed: 17998650
Clin Nutr. 2008 Jun;27(3):371-7
pubmed: 18485542
Int J Gynecol Pathol. 1999 Apr;18(2):115-21
pubmed: 10202667
Gynecol Oncol. 2013 Jan;128(1):44-48
pubmed: 23138134
Anal Chem. 2010 Sep 1;82(17):7343-50
pubmed: 20681559
Gynecol Obstet Invest. 2012;73(3):230-5
pubmed: 22442250
Sci Transl Med. 2013 Jul 17;5(194):194ra93
pubmed: 23863833
Gynecol Oncol. 2012 Jun;125(3):604-9
pubmed: 22406639
N Engl J Med. 2018 Nov 15;379(20):1895-1904
pubmed: 30380365