The combination of ibrutinib and rituximab demonstrates activity in first-line follicular lymphoma.


Journal

British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544

Informations de publication

Date de publication:
05 2020
Historique:
received: 13 09 2019
revised: 01 11 2019
accepted: 04 11 2019
pubmed: 18 3 2020
medline: 13 1 2021
entrez: 18 3 2020
Statut: ppublish

Résumé

This phase 2 study evaluated the activity and safety of ibrutinib, a Bruton's tyrosine kinase inhibitor, plus rituximab in adults with previously untreated follicular lymphoma. Patients received once-daily ibrutinib 560 mg continuously plus once-weekly rituximab 375 mg/m

Identifiants

pubmed: 32180219
doi: 10.1111/bjh.16424
pmc: PMC7317728
doi:

Substances chimiques

Piperidines 0
ibrutinib 1X70OSD4VX
Rituximab 4F4X42SYQ6
Adenine JAC85A2161

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

650-660

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Pharmacyclics, LLC, an AbbVie Company
ID : Not applicable
Pays : International

Informations de copyright

© 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

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Auteurs

Nathan H Fowler (NH)

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Loretta Nastoupil (L)

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Sven De Vos (S)

David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.

Mark Knapp (M)

Zangmeister Cancer Center, Columbus, OH, USA.

Ian W Flinn (IW)

Sarah Cannon Research Institute, Nashville, TN, USA.

Robert Chen (R)

City of Hope, Duarte, CA, USA.

Ranjana H Advani (RH)

Stanford University School of Medicine, Stanford, CA, USA.

Sumeet Bhatia (S)

Community Health Network, Indianapolis, IN, USA.

Peter Martin (P)

Weill Cornell Medical College, New York, NY, USA.

Raul Mena (R)

Providence St. Joseph Medical Center, Burbank, CA, USA.

Richard Eric Davis (RE)

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Sattva S Neelapu (SS)

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Karl Eckert (K)

Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.

Jerry Ping (J)

Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.

Melannie Co (M)

Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.

Darrin M Beaupre (DM)

Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.

Jutta K Neuenburg (JK)

Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.

M Lia Palomba (ML)

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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Classifications MeSH