Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits.
astrocyte
locomotion
mGlu receptor5
neuromodulation
spinal cord
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
11
2019
accepted:
03
02
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
18
3
2020
Statut:
epublish
Résumé
Evidence suggests that astrocytes are not merely supportive cells in the nervous system but may actively participate in the control of neural circuits underlying cognition and behavior. In this study, we examined the role of astrocytes within the motor circuitry of the mammalian spinal cord. Pharmacogenetic manipulation of astrocytic activity in isolated spinal cord preparations obtained from neonatal mice revealed astrocyte-derived, adenosinergic modulation of the frequency of rhythmic output generated by the locomotor central pattern generator (CPG) network. Live Ca
Identifiants
pubmed: 32180706
doi: 10.3389/fncel.2020.00030
pmc: PMC7057799
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30Informations de copyright
Copyright © 2020 Broadhead and Miles.
Références
J Neurophysiol. 2011 May;105(5):2108-20
pubmed: 21346211
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E756-65
pubmed: 23388633
Cell. 2019 May 16;177(5):1280-1292.e20
pubmed: 31031006
J Neurophysiol. 2018 Sep 1;120(3):998-1009
pubmed: 29790837
Neuron. 2013 Mar 20;77(6):1047-54
pubmed: 23522041
Neural Plast. 2013;2013:185463
pubmed: 24369508
Neuron. 2006 Dec 7;52(5):751-66
pubmed: 17145498
Neuroscience. 2016 May 26;323:29-34
pubmed: 25847307
J Physiol. 1998 Aug 15;511 ( Pt 1):265-72
pubmed: 9679180
PLoS One. 2015 Aug 07;10(8):e0134488
pubmed: 26252389
J Neurophysiol. 2012 Apr;107(7):1925-34
pubmed: 22205649
Physiology (Bethesda). 2011 Dec;26(6):393-411
pubmed: 22170958
Int J Mol Sci. 2018 Oct 05;19(10):
pubmed: 30301132
Neurosci Biobehav Rev. 2008 Jul;32(5):927-44
pubmed: 18462796
J Neurochem. 1996 Apr;66(4):1383-90
pubmed: 8627289
Cell Rep. 2015 May 5;11(5):798-807
pubmed: 25921535
Curr Opin Neurobiol. 2011 Oct;21(5):685-92
pubmed: 21646013
J Physiol. 2012 Jan 15;590(2):335-50
pubmed: 22063626
J Neurosci. 2010 Mar 17;30(11):3947-58
pubmed: 20237265
Glia. 2017 May;65(5):699-711
pubmed: 28168732
Mol Neurobiol. 2019 Feb;56(2):797-811
pubmed: 29797183
Neurosci Biobehav Rev. 2017 Jun;77:87-97
pubmed: 28279812
Nat Commun. 2018 Oct 12;9(1):4254
pubmed: 30315174
Nat Commun. 2018 Jan 25;9(1):370
pubmed: 29371650
Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G1-G14
pubmed: 27789457
Nature. 1984 Oct 18-24;311(5987):656-9
pubmed: 6148706
Cell Mol Neurobiol. 2005 Mar;25(2):223-44
pubmed: 16050035
Sci Rep. 2014 Feb 17;4:4106
pubmed: 24531181
J Physiol. 2012 Oct 1;590(19):4933-44
pubmed: 22777672
Eur J Neurosci. 2010 Jul;32(1):29-40
pubmed: 20608967
Glia. 2016 Mar;64(3):363-73
pubmed: 26496414
Glia. 2016 Dec;64(12):2263-2273
pubmed: 27658520
J Physiol. 2018 Oct;596(20):4983-4994
pubmed: 30079574
Neuropharmacology. 2016 Feb;101:490-505
pubmed: 26493631
Neuron Glia Biol. 2006 Nov;2(4):259-69
pubmed: 17710215
Nature. 1996 Sep 19;383(6597):259-63
pubmed: 8805702
Cell. 2019 May 16;177(5):1091-1093
pubmed: 31100265
J Neurosci. 2009 Sep 23;29(38):11723-31
pubmed: 19776259
Neurochem Res. 2012 Nov;37(11):2310-6
pubmed: 22481627
Nat Med. 2006 Jul;12(7):829-34
pubmed: 16783372
Nat Commun. 2016 Apr 28;7:11450
pubmed: 27121084
Nat Neurosci. 2015 Jun;18(6):844-54
pubmed: 25938883
J Physiol. 2000 Jun 15;525 Pt 3:655-67
pubmed: 10856119
J Neurophysiol. 2015 Oct;114(4):2305-15
pubmed: 26311185
Front Neural Circuits. 2014 Jun 04;8:60
pubmed: 24926236
Curr Pharm Des. 2017;23(33):5010-5021
pubmed: 28641533
Exp Brain Res. 1987;65(2):482-5
pubmed: 3556475
Nat Rev Neurosci. 2016 Apr;17(4):224-38
pubmed: 26935168
Neurobiol Dis. 2013 Nov;59:244-56
pubmed: 23959140
Glia. 2017 Mar;65(3):447-459
pubmed: 27896839
Neurochem Int. 2008 Jan;52(1-2):142-54
pubmed: 17669556
J Physiol. 2011 Jul 1;589(Pt 13):3333-48
pubmed: 21558161
Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12150-5
pubmed: 16880388
J Neurosci. 2018 Jan 3;38(1):3-13
pubmed: 29298904
J Physiol. 2017 Dec 1;595(23):7063-7079
pubmed: 28734063
J Neurophysiol. 2017 Dec 1;118(6):3311-3327
pubmed: 28954893
Neuroscience. 1999;91(3):1171-81
pubmed: 10391492
Science. 2013 Jan 11;339(6116):197-200
pubmed: 23307741
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):59-68
pubmed: 19712903
J Neurosci. 2018 Jan 3;38(1):14-25
pubmed: 29298905
Glia. 2016 Jul;64(7):1154-69
pubmed: 27083773
Gastroenterology. 2014 Feb;146(2):497-507.e1
pubmed: 24211490
Nat Rev Gastroenterol Hepatol. 2012 Nov;9(11):625-32
pubmed: 22890111
Nat Rev Neurosci. 2003 Jul;4(7):573-86
pubmed: 12838332
Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):631-645
pubmed: 26693173
Neurotherapeutics. 2010 Oct;7(4):482-93
pubmed: 20880510
Science. 2010 Jul 30;329(5991):571-5
pubmed: 20647426