Impaired B Cell Function in Mice Lacking Perforin-2.
adipose tissue B cells
antibody responses
inflammation
perforin-2
splenic B cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
10
2019
accepted:
10
02
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
26
3
2021
Statut:
epublish
Résumé
Perforin-2 (P2) is a pore-forming protein with cytotoxic activity against intracellular bacterial pathogens. P2 knockout (P2KO) mice are unable to control infections and die from normally non-lethal bacterial infections. Here we show that P2KO mice as compared to WT mice show significantly higher levels of systemic inflammation, measured by inflammatory markers in serum, due to continuous microbial translocation from the gut which cannot be controlled as these mice lack P2. Systemic inflammation in young and old P2KO mice induces intrinsic B cell inflammation. Systemic and B cell intrinsic inflammation are negatively associated with
Identifiants
pubmed: 32180773
doi: 10.3389/fimmu.2020.00328
pmc: PMC7057857
doi:
Substances chimiques
Influenza Vaccines
0
Pore Forming Cytotoxic Proteins
0
perforin 2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
328Subventions
Organisme : NIA NIH HHS
ID : R01 AG023717
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR015649
Pays : United States
Informations de copyright
Copyright © 2020 Frasca, Diaz, Romero, Vazquez, Strbo, Romero, McCormack, Podack and Blomberg.
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