Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia
Alzheimer’s disease
STAT6
astroglia
interleukin-4
mouse
neurogenesis
regeneration
zebrafish
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
12
2019
accepted:
10
02
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
18
3
2020
Statut:
epublish
Résumé
Recent findings suggest that reduced neurogenesis could be one of the underlying reasons for the exacerbated neuropathology in humans, thus restoring the neural stem cell proliferation and neurogenesis could help to circumvent some pathological aspects of Alzheimer's disease. We recently identified Interleukin-4/STAT6 signaling as a neuron-glia crosstalk mechanism that enables glial proliferation and neurogenesis in adult zebrafish brain and 3D cultures of human astroglia, which manifest neurogenic properties. In this study, by using single cell sequencing in the APP/PS1dE9 mouse model of AD, we found that IL4 receptor (
Identifiants
pubmed: 32181251
doi: 10.3389/fcell.2020.00114
pmc: PMC7057913
doi:
Types de publication
Journal Article
Langues
eng
Pagination
114Informations de copyright
Copyright © 2020 Mashkaryan, Siddiqui, Popova, Cosacak, Bhattarai, Brandt, Govindarajan, Petzold, Reinhardt, Dahl, Lefort and Kizil.
Références
Nature. 2003 Dec 18;426(6968):900-4
pubmed: 14685251
J Alzheimers Dis. 2018;64(s1):S497-S505
pubmed: 29562522
Science. 2012 Dec 7;338(6112):1353-6
pubmed: 23138980
Neural Regen Res. 2020 May;15(5):824-827
pubmed: 31719242
Biomed Res Int. 2015;2015:769763
pubmed: 26417601
J Anat. 2011 Jul;219(1):78-89
pubmed: 21323664
Cell Stem Cell. 2019 Jul 3;25(1):7-8
pubmed: 31271749
Nature. 2019 Sep;573(7772):61-68
pubmed: 31435019
Clin Cancer Res. 2008 Oct 15;14(20):6640-6
pubmed: 18927306
J Vis Exp. 2009 Nov 17;(33):
pubmed: 19920804
Nature. 1997 Oct 16;389(6652):677-8
pubmed: 9338775
Neurogenesis (Austin). 2017 May 2;4(1):e1322666
pubmed: 28656156
Cancer Res. 2001 Nov 15;61(22):8058-61
pubmed: 11719427
Yale J Biol Med. 2016 Mar 24;89(1):23-35
pubmed: 27505014
Nat Rev Neurosci. 2015 Jun;16(6):358-72
pubmed: 25991443
J Alzheimers Dis. 2015;44(3):949-62
pubmed: 25374107
Science. 2002 Oct 25;298(5594):789-91
pubmed: 12399581
Science. 2018 Jun 1;360(6392):
pubmed: 29700225
Sci Rep. 2017 Oct 11;7(1):12959
pubmed: 29021554
J Immunol. 2012 Nov 1;189(9):4213-9
pubmed: 23087426
Curr Alzheimer Res. 2011 Dec;8(8):818-31
pubmed: 21592052
Cell Death Dis. 2013 Nov 21;4:e924
pubmed: 24263098
Biochim Biophys Acta. 2011 Mar;1812(3):346-52
pubmed: 20920580
Curr Opin Genet Dev. 2003 Oct;13(5):543-50
pubmed: 14550422
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Environ Health Perspect. 2005 Sep;113(9):1250-6
pubmed: 16140637
Crit Rev Oncog. 1998;9(3-4):255-68
pubmed: 10201630
J Biol Chem. 2008 Jan 25;283(4):1808-17
pubmed: 17981803
Science. 2016 Nov 4;354(6312):630-634
pubmed: 27811277
Oncotarget. 2016 Dec 27;7(52):86836-86856
pubmed: 27895317
Immunology. 2010 Feb;129(2):154-69
pubmed: 20561356
Nature. 2013 Jan 31;493(7434):674-8
pubmed: 23254930
Neurobiol Aging. 2005 May;26(5):717-28
pubmed: 15708447
Science. 2003 Jun 6;300(5625):1527-8
pubmed: 12791978
Brain Behav Immun. 2009 Oct;23(7):1020-7
pubmed: 19501645
Nat Rev Genet. 2007 May;8(5):353-67
pubmed: 17440532
Cell Rep. 2019 Apr 23;27(4):1307-1318.e3
pubmed: 31018142
PLoS Biol. 2020 Jan 6;18(1):e3000585
pubmed: 31905199
PLoS One. 2008 Aug 13;3(8):e2935
pubmed: 18698410
Neurobiol Dis. 2010 Nov;40(2):386-93
pubmed: 20615468
Proc Natl Acad Sci U S A. 1989 May;86(10):3803-7
pubmed: 2786204
Curr Alzheimer Res. 2016;13(8):894-911
pubmed: 26825092
Dev Cell. 2012 Dec 11;23(6):1230-7
pubmed: 23168169
Front Cell Dev Biol. 2018 Nov 23;6:159
pubmed: 30533414
Cell Rep. 2016 Oct 18;17(4):941-948
pubmed: 27760324
Trends Neurosci. 2015 Mar;38(3):145-57
pubmed: 25579391
Neurobiol Aging. 2015 Sep;36(9):2519-32
pubmed: 26089165
Brain Res Bull. 2002 Apr;57(6):751-8
pubmed: 12031271
Neuromolecular Med. 2002;1(2):125-35
pubmed: 12025858
FASEB J. 2010 Aug;24(8):3093-102
pubmed: 20371618
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Exp Neurol. 2009 Jan;215(1):5-19
pubmed: 18938162
J Neurochem. 2007 May;101(3):771-81
pubmed: 17250684
Curr Pathobiol Rep. 2018;6(1):71-77
pubmed: 29938129
Mol Neurodegener. 2017 Sep 8;12(1):64
pubmed: 28886753
Nature. 2000 Dec 21-28;408(6815):975-9
pubmed: 11140684
Development. 2003 Jan;130(2):391-9
pubmed: 12466205
J Exp Med. 2015 Mar 9;212(3):287-95
pubmed: 25732305
Nat Rev Drug Discov. 2019 Oct;18(11):811-813
pubmed: 31673135
FEBS Lett. 1996 Sep 9;393(1):53-6
pubmed: 8804422
Int J Cancer. 1994 Aug 15;58(4):574-81
pubmed: 8056454
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Nat Neurosci. 2003 Nov;6(11):1127-34
pubmed: 14583753
J Psychosom Res. 2006 Sep;61(3):311-6
pubmed: 16938507
Mol Ther. 2012 Jun;20(6):1167-76
pubmed: 22472951
Mol Neurobiol. 2016 Oct;53(8):5796-806
pubmed: 27544234
Dev Dyn. 2003 Feb;226(2):202-10
pubmed: 12557199
Cancer Res. 2014 Aug 15;74(16):4329-40
pubmed: 24947041
Physiol Rev. 2001 Apr;81(2):741-66
pubmed: 11274343
J Neuroimmunol. 1994 Sep;53(2):209-18
pubmed: 8071435
Trends Genet. 2013 Nov;29(11):611-20
pubmed: 23927865
Nat Biotechnol. 2016 Mar;34(3):303-11
pubmed: 26829319
Mol Neurodegener. 2011 Dec 22;6:85
pubmed: 22192775
Retrovirology. 2010 May 17;7:45
pubmed: 20478027
Lancet. 2006 Jul 29;368(9533):387-403
pubmed: 16876668
Nat Med. 2019 Apr;25(4):554-560
pubmed: 30911133
Mol Neurodegener. 2012 Jul 29;7:36
pubmed: 22838967
Elife. 2016 Oct 01;5:
pubmed: 27692071
Cell. 2016 Feb 11;164(4):603-15
pubmed: 26871627
J Neurochem. 2002 Dec;83(6):1509-24
pubmed: 12472904
Science. 2003 Dec 5;302(5651):1760-5
pubmed: 14615545
Nature. 2011 Feb 3;470(7332):95-100
pubmed: 21270795
Prog Neurobiol. 2011 Feb;93(2):149-64
pubmed: 21056616
J Neuroimmunol. 1995 Jul;60(1-2):75-81
pubmed: 7642750
J Vis Exp. 2017 Oct 25;(128):
pubmed: 29155703
Neurobiol Dis. 2011 Sep;43(3):616-24
pubmed: 21624466
Sci Rep. 2017 Aug 30;7(1):10085
pubmed: 28855626
Genome Res. 1999 Feb;9(2):99-100
pubmed: 10022974
J Neurosci Res. 2002 Dec 15;70(6):734-45
pubmed: 12444595
Dev Neurobiol. 2012 Mar;72(3):429-61
pubmed: 21595047
J Biol Chem. 2005 Mar 11;280(10):9354-62
pubmed: 15615726
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Science. 2018 Sep 7;361(6406):
pubmed: 30190379
J Immunol. 2003 Oct 1;171(7):3627-35
pubmed: 14500660
Nat Rev Drug Discov. 2015 Oct;14(10):721-31
pubmed: 26361349
Brain Behav Evol. 2001;58(5):306-22
pubmed: 11978948
Blood. 2007 Dec 15;110(13):4367-9
pubmed: 17878403
Acta Neuropathol. 2015 Feb;129(2):207-20
pubmed: 25492702
J Immunol. 2010 Mar 15;184(6):3186-90
pubmed: 20147633
Front Cell Neurosci. 2019 Feb 11;13:23
pubmed: 30809125
J Exp Med. 2011 May 9;208(5):937-48
pubmed: 21482697
Cell. 1999 Jun 11;97(6):703-16
pubmed: 10380923
Ann N Y Acad Sci. 2006 May;1067:454-60
pubmed: 16804026
Carcinogenesis. 2010 Jun;31(6):1010-7
pubmed: 20176658
J Vis Exp. 2014 Feb 25;(84):e51225
pubmed: 24637893
Neuropharmacology. 2014 Jan;76 Pt A:57-67
pubmed: 23973293
J Comp Neurol. 2006 Mar 1;495(1):70-83
pubmed: 16432899
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7
pubmed: 14581618
Dev Cell. 2018 Jul 2;46(1):85-101.e8
pubmed: 29974866
Curr Opin Drug Discov Devel. 2003 Mar;6(2):218-23
pubmed: 12669457
J Neurochem. 2009 Mar;108(5):1155-66
pubmed: 19141080
Stem Cell Reports. 2019 Mar 5;12(3):502-517
pubmed: 30773488