Evaluation of the neuropharmacological effects of Gardenin A in mice.
Animals
Anti-Anxiety Agents
/ therapeutic use
Anticonvulsants
/ therapeutic use
Antidepressive Agents
/ therapeutic use
Behavior, Animal
/ drug effects
Exploratory Behavior
/ drug effects
Flavones
/ therapeutic use
Hypnotics and Sedatives
/ therapeutic use
Male
Mice, Inbred BALB C
Rotarod Performance Test
Seizures
/ chemically induced
Strychnine
Swimming
Gardenin a
anxiety
convulsion
depression
sedative
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
07
01
2020
revised:
29
02
2020
accepted:
03
03
2020
pubmed:
18
3
2020
medline:
2
9
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
This work describes the neuropharmacological (sedative, anxiolytic, antidepressant, and anticonvulsant) actions of Gardenin A (GA) (0.1-25 mg/kg p.o.), a flavonoid found in medicinal plants. The sedative effects of GA were assessed with the pentobarbital-induced sleep test. The anxiolytic actions of GA were evaluated with the elevated plus-maze, the light-dark box test, the exploratory cylinder assay, and the open field test. Motor coordination was evaluated with the rotarod test and the open field test. The antidepressant-like actions of GA were evaluated with the tail suspension test and forced swimming test. The mechanisms of the anxiolytic-like and antidepressant-like effects of GA were assessed using inhibitors of neurotransmission pathways. The anticonvulsant activity of GA was evaluated with the strychnine-induced seizure test. The sedative effects of GA were evident only at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset. GA showed anxiolytic-like actions with activity comparable to that of clonazepam in all experimental tests. The GABA
Substances chimiques
Anti-Anxiety Agents
0
Anticonvulsants
0
Antidepressive Agents
0
Flavones
0
Hypnotics and Sedatives
0
gardenin A
24J0W87Z43
Strychnine
H9Y79VD43J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-608Subventions
Organisme : Secretaría de Salud del Estado de Guanajuato
ID : Evaluacion de los efectos antidepresivos y antibio
Pays : International
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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