Vulvar pruritus-Causes, Diagnosis and Therapeutic Approach.


Journal

Deutsches Arzteblatt international
ISSN: 1866-0452
Titre abrégé: Dtsch Arztebl Int
Pays: Germany
ID NLM: 101475967

Informations de publication

Date de publication:
21 02 2020
Historique:
received: 16 05 2019
revised: 16 05 2019
accepted: 27 11 2019
entrez: 18 3 2020
pubmed: 18 3 2020
medline: 15 4 2020
Statut: ppublish

Résumé

In Germany, 17-23% of the population suffers from chronic itching of the skin; in 5-10% of cases, the female genitalia are affected, specifically, the vulva. Vulvar pruritus is thus a common symptom that often markedly impairs the affected women's quality of life. This review is based on pertinent publications that were retrieved by a selective search in MEDLINE/PubMed for articles on the pathogenesis, diagnosis, and treatment of vul- var pruritus. The search terms were (in German and English) "vulvärer Juckreiz," "pruritus vulvae," and "genital itch," alone and in combination with "Behandlung," "Therapie," or "treat- ment." The most common cause of vulvar pruritus is vulvo- vaginal candidiasis followed by chronic dermatoses, such as lichen sclerosus and vulvar eczema. Especially in refractory cases, an invasive or preinvasive lesion such as squamous epithelial dysplasia (VIN, vulvar intraepithelial neoplasia) should be borne in mind in the differential diagnosis. Rarer causes include infection, atrophy, and vulvodynia. The essen- tial elements of treatment are topical/oral antimycotic drugs and high-potency glucocorticoids, along with consistently ap- plied, basic moisturizing care and the avoidance of potential triggering factors. As vulvar pruritus has multiple causes, standard- ization of its diagnostic evaluation and treatment would be l efficacy and to meet the diverse needs of women who suffer from this condition.

Sections du résumé

BACKGROUND
In Germany, 17-23% of the population suffers from chronic itching of the skin; in 5-10% of cases, the female genitalia are affected, specifically, the vulva. Vulvar pruritus is thus a common symptom that often markedly impairs the affected women's quality of life.
METHODS
This review is based on pertinent publications that were retrieved by a selective search in MEDLINE/PubMed for articles on the pathogenesis, diagnosis, and treatment of vul- var pruritus. The search terms were (in German and English) "vulvärer Juckreiz," "pruritus vulvae," and "genital itch," alone and in combination with "Behandlung," "Therapie," or "treat- ment."
RESULTS
The most common cause of vulvar pruritus is vulvo- vaginal candidiasis followed by chronic dermatoses, such as lichen sclerosus and vulvar eczema. Especially in refractory cases, an invasive or preinvasive lesion such as squamous epithelial dysplasia (VIN, vulvar intraepithelial neoplasia) should be borne in mind in the differential diagnosis. Rarer causes include infection, atrophy, and vulvodynia. The essen- tial elements of treatment are topical/oral antimycotic drugs and high-potency glucocorticoids, along with consistently ap- plied, basic moisturizing care and the avoidance of potential triggering factors.
CONCLUSION
As vulvar pruritus has multiple causes, standard- ization of its diagnostic evaluation and treatment would be l efficacy and to meet the diverse needs of women who suffer from this condition.

Identifiants

pubmed: 32181734
pii: arztebl.2020.0126
doi: 10.3238/arztebl.2020.0126
pmc: PMC7081372
doi:
pii:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-133

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Références

Lancet. 2003 Jul 12;362(9378):118-23
pubmed: 12867112
Australas J Dermatol. 2004 Feb;45(1):12-5
pubmed: 14961902
Acta Derm Venereol. 2013 Mar 27;93(2):238-41
pubmed: 23224274
Am J Clin Dermatol. 2004;5(2):105-25
pubmed: 15109275
Nat Neurosci. 2014 Feb;17(2):175-82
pubmed: 24473265
Am J Dermatopathol. 2000 Feb;22(1):7-16
pubmed: 10698209
Hautarzt. 2012 Nov;63(11):868-71
pubmed: 22925897
Mycoses. 2015 Mar;58 Suppl 1:1-15
pubmed: 25711406
Arch Dermatol. 1990 Aug;126(8):1043-5
pubmed: 2200345
J Reprod Med. 1993 Jan;38(1):25-7
pubmed: 8441126
BJOG. 2011 Apr;118(5):533-49
pubmed: 21251190
Arch Gynecol Obstet. 2006 Aug;274(5):266-70
pubmed: 16830155
Pediatr Dermatol. 2003 May-Jun;20(3):191-4
pubmed: 12787264
N Engl J Med. 2013 Apr 25;368(17):1625-34
pubmed: 23614588
Future Microbiol. 2011 Apr;6(4):441-57
pubmed: 21526945
Dermatology. 2011;223(2):152-60
pubmed: 21997592
J Clin Diagn Res. 2016 Apr;10(4):WE01-3
pubmed: 27190932
J Dtsch Dermatol Ges. 2017 Aug;15(8):860-873
pubmed: 28763608
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Obstet Gynecol. 2018 Feb;131(2):371-386
pubmed: 29324620
Dermatol Ther. 2015 Jul-Aug;28(4):210-5
pubmed: 25973931
Int J STD AIDS. 2018 Nov;29(13):1258-1272
pubmed: 30049258
Bone Marrow Transplant. 2001 Nov;28(9):873-8
pubmed: 11781648
Lett Appl Microbiol. 2009 Mar;48(3):269-74
pubmed: 19187507
J Eur Acad Dermatol Venereol. 2010 Sep;24(9):1031-4
pubmed: 20202060
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Apr;105(4):457-9
pubmed: 18329581
Ann Intern Med. 1992 Mar 1;116(5):353-7
pubmed: 1736766
Dermatology. 2001;202(3):198-202
pubmed: 11385223
Chem Biodivers. 2012 May;9(5):965-76
pubmed: 22589096
Br J Dermatol. 2000 Mar;142(3):481-4
pubmed: 10735954
Genitourin Med. 1988 Apr;64(2):118-23
pubmed: 3290091
J Am Acad Dermatol. 2001 May;44(5):803-6
pubmed: 11312428
Dermatol Clin. 2001 Jan;19(1):179-97, x
pubmed: 11155582
Am J Obstet Gynecol. 2001 Sep;185(3):545-50
pubmed: 11568775
Evid Based Complement Alternat Med. 2015;2015:208690
pubmed: 26064156
Lancet. 2007 May 5;369(9572):1519-1527
pubmed: 17482982
Trends Endocrinol Metab. 2011 Oct;22(10):389-93
pubmed: 21757370
Arch Dermatol. 2008 Nov;144(11):1432-5
pubmed: 19015417
Clin Colon Rectal Surg. 2016 Mar;29(1):38-42
pubmed: 26929750
J Eur Acad Dermatol Venereol. 2015 Oct;29(10):e1-43
pubmed: 26202852
J Low Genit Tract Dis. 2013 Jul;17(3):340-5
pubmed: 23486072
Br J Dermatol. 2006 Nov;155(5):931-40
pubmed: 17034521
Mycoses. 2012 May;55(3):e85-9
pubmed: 21895786
Am J Obstet Gynecol. 2016 Jan;214(1):15-21
pubmed: 26164695
Br J Dermatol. 1988 Jan;118(1):41-6
pubmed: 3342175
Br J Dermatol. 1995 Feb;132(2):197-203
pubmed: 7888355
Clin Infect Dis. 2006 Jan 15;42(2):244-51
pubmed: 16355336
Clin Exp Dermatol. 2004 Sep;29(5):499-504
pubmed: 15347336
Br J Dermatol. 2009 Nov;161(5):1136-42
pubmed: 19558556
J Am Acad Dermatol. 2004 Jun;50(6):889-91
pubmed: 15153889
Gynakol Rundsch. 1991;31(3):153-60
pubmed: 1761240
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7
pubmed: 20534435
Nat Neurosci. 2001 Jan;4(1):9-10
pubmed: 11135635
Menopause. 2015 Aug;22(8):850-6
pubmed: 25608275
Clin Infect Dis. 2016 Feb 15;62(4):e1-50
pubmed: 26679628
JAMA Dermatol. 2015 Oct;151(10):1061-7
pubmed: 26070005
Br J Dermatol. 1986 Mar;114(3):377-9
pubmed: 3954957
BJOG. 2006 Jul;113(7):832-4
pubmed: 16827768
Clin Obstet Gynecol. 2005 Dec;48(4):786-807
pubmed: 16286826
J Eur Acad Dermatol Venereol. 2017 Jun;31(6):925-941
pubmed: 28164373
Z Evid Fortbild Qual Gesundhwes. 2012;106(6):449-56
pubmed: 22857733
J Low Genit Tract Dis. 2010 Oct;14(4):319-22
pubmed: 20885159
J Clin Microbiol. 1996 Oct;34(10):2497-9
pubmed: 8880507
Am J Obstet Gynecol. 2003 Nov;189(5):1297-300
pubmed: 14634557
J Low Genit Tract Dis. 2011 Oct;15(4):287-91
pubmed: 21959572
Lancet. 2003 Dec 6;362(9399):1871-6
pubmed: 14667741
Microbes Infect. 2010 Sep;12(10):691-9
pubmed: 20472091
Arch Dermatol. 2008 May;144(5):591-8
pubmed: 18490585
Dermatol Ther. 2004;17(1):8-19
pubmed: 14756886

Auteurs

Linn Woelber (L)

Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infections in Gynecology and Obstetrics, Wuppertal, Germany; Institute of Fungal Disease and Internal Medicine, Mycoclinic Berlin, Berlin, Germany.

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Classifications MeSH