Non-motor symptom burden is strongly correlated to motor complications in patients with Parkinson's disease.
Parkinson’s disease
dyskinesia
fatigue
motor fluctuations
non-motor symptoms
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
12
09
2019
accepted:
05
03
2020
pubmed:
18
3
2020
medline:
22
6
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
The objective of this study was to analyze the relationship between motor complications and non-motor symptom (NMS) burden in a population of patients with Parkinson's disease (PD) and also in a subgroup of patients with early PD. Patients with PD from the COPPADIS cohort were included in this cross-sectional study. NMS burden was defined according to the Non-Motor Symptoms Scale (NMSS) total score. Unified Parkinson's Disease Rating Scale (UPDRS) part IV was used to establish motor complication types and their severity. Patients with ≤5 years of symptoms from onset were included as patients with early PD. Of 690 patients with PD (62.6 ± 8.9 years old, 60.1% males), 33.9% and 18.1% presented motor fluctuations and dyskinesia, respectively. The NMS total score was higher in patients with motor fluctuations (59.2 ± 43.1 vs. 38.3 ± 33.1; P < 0.0001) and dyskinesia (63.5 ± 40.7 vs. 41.4 ± 36.3; P < 0.0001). In a multiple linear regression model and after adjustment for age, sex, disease duration, Hoehn & Yahr stage, UPDRS-III score and levodopa equivalent daily dose, UPDRS-IV score was significantly related to a higher NMSS total score (β = 0.27; 95% confidence intervals, 2.81-5.61; P < 0.0001), as it was in a logistic regression model on dichotomous NMSS total score (≤40, mild or moderate vs. >40, severe or very severe) (odds ratio, 1.31; 95% confidence intervals, 1.17-1.47; P < 0.0001). In the subgroup of patients with early PD (n = 396; mean disease duration 2.7 ± 1.5 years), motor fluctuations were frequent (18.1%) and similar results were obtained. Motor complications were frequent and were associated with a greater NMS burden in patients with PD even during the first 5 years of disease duration.
Sections du résumé
BACKGROUND AND PURPOSE
The objective of this study was to analyze the relationship between motor complications and non-motor symptom (NMS) burden in a population of patients with Parkinson's disease (PD) and also in a subgroup of patients with early PD.
METHODS
Patients with PD from the COPPADIS cohort were included in this cross-sectional study. NMS burden was defined according to the Non-Motor Symptoms Scale (NMSS) total score. Unified Parkinson's Disease Rating Scale (UPDRS) part IV was used to establish motor complication types and their severity. Patients with ≤5 years of symptoms from onset were included as patients with early PD.
RESULTS
Of 690 patients with PD (62.6 ± 8.9 years old, 60.1% males), 33.9% and 18.1% presented motor fluctuations and dyskinesia, respectively. The NMS total score was higher in patients with motor fluctuations (59.2 ± 43.1 vs. 38.3 ± 33.1; P < 0.0001) and dyskinesia (63.5 ± 40.7 vs. 41.4 ± 36.3; P < 0.0001). In a multiple linear regression model and after adjustment for age, sex, disease duration, Hoehn & Yahr stage, UPDRS-III score and levodopa equivalent daily dose, UPDRS-IV score was significantly related to a higher NMSS total score (β = 0.27; 95% confidence intervals, 2.81-5.61; P < 0.0001), as it was in a logistic regression model on dichotomous NMSS total score (≤40, mild or moderate vs. >40, severe or very severe) (odds ratio, 1.31; 95% confidence intervals, 1.17-1.47; P < 0.0001). In the subgroup of patients with early PD (n = 396; mean disease duration 2.7 ± 1.5 years), motor fluctuations were frequent (18.1%) and similar results were obtained.
CONCLUSIONS
Motor complications were frequent and were associated with a greater NMS burden in patients with PD even during the first 5 years of disease duration.
Substances chimiques
Levodopa
46627O600J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1210-1223Investigateurs
Daniela Astrid Adarmes
(D)
Marta Almeria
(M)
Maria Gema Alonso Losada
(MG)
Araceli Alonso Cánovas
(A)
María Álvarez Sauco
(M)
Sandra Arnáiz
(S)
Sonia Arribas
(S)
Arancha Ascunce Vidondo
(A)
Noemí Bernardo Lambrich
(N)
Helena Bejr-Kasem
(H)
Marta Blázquez Estrada
(M)
Maria Ángeles Botí González
(MÁ)
Carmen Borrué
(C)
Carolina Cabello González
(C)
Ana Cámara Lorenzo
(A)
Fátima Carrillo
(F)
Francisco José Carrillo Padilla
(FJ)
Elena Casas
(E)
Pedro Clavero
(P)
A Cortina Fernández
(A)
Anna Cots Foraster
(A)
Ane Crespo Cuevas
(A)
Esther Cubo
(E)
Oriol De Fábregues-Boixar
(O)
M Díez Fairen
(M)
Elena Erro
(E)
Sonia Escalante
(S)
Noelia Fernández Guillán
(N)
Pedro Gámez
(P)
Mercedes Gallego
(M)
Cristina García Campos
(C)
Jose Manuel García Moreno
(JM)
Itziar Gastón
(I)
María Del Pilar Gómez Garre
(MDP)
Javier González Aloy
(J)
Isabel González Aramburu
(I)
Jessica González Ardura
(J)
Beatriz González García
(B)
Maria Josefa González Palmás
(MJ)
Gabriel Ricardo González Toledo
(GR)
Ana Golpe Díaz
(A)
Mireia Grau Solá
(M)
Gemma Guardia
(G)
Andrea Horta Barba
(A)
Jon Infante
(J)
Jaime Kulisevsky
(J)
Mónica Kurtis
(M)
Carmen Labandeira
(C)
Miguel Ángel Labrador Espinosa
(MÁ)
Francisco Lacruz
(F)
Melva Lage Castro
(M)
Inés Legarda
(I)
N López Ariztegui
(N)
Luis Manuel López Díaz
(LM)
Balbino López Seoane
(B)
Yolanda Macías
(Y)
Marina Mata
(M)
Juan Carlos Martínez Castrillo
(JC)
Maria Teresa Meitín
(MT)
Manuel Menéndez González
(M)
Carlota Méndez Del Barrio
(C)
Javier Miranda Santiago
(J)
Maria Isabel Morales Casado
(MI)
Antonio Moreno Diéguez
(A)
Víctor Nogueira
(V)
Alba Novo Amado
(A)
Sabela Novo Ponte
(S)
Carlos Ordás
(C)
Javier Pagonabarraga
(J)
Pareés Isabel
(P)
Berta Pascual-Sedano
(B)
Aída Pérez Fuertes
(A)
Rafael Pérez Noguera
(R)
Marian Ángeles Prats
(MÁ)
Cristina Prieto Jurczynska
(C)
Víctor Puente
(V)
Mercedes Pueyo Morlans
(M)
Luisa Rodríguez Méndez
(L)
Amparo Belén Rodríguez Pérez
(AB)
Florinda Roldán
(F)
María Ruíz de Arcos
(M)
Javier Ruíz Martínez
(J)
Pilar Sánchez Alonso
(P)
Macarena Sánchez-Carpintero
(M)
Gema Sánchez Díez
(G)
Antonio Sánchez Rodríguez
(A)
Pilar Santacruz
(P)
José Clemente Segundo Rodríguez
(JC)
Manuel Seijo
(M)
Agustí Serarols
(A)
María Sierra
(M)
Berta Solano
(B)
Juan Pablo Tartari
(JP)
Caridad Valero
(C)
Laura Vargas
(L)
Ricardo Vázquez Gómez
(R)
Lydia Vela
(L)
Bárbara Vives
(B)
Maria Dolores Villa
(MD)
Informations de copyright
© 2020 European Academy of Neurology.
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