Small-area methods for investigation of environment and health.
Journal
International journal of epidemiology
ISSN: 1464-3685
Titre abrégé: Int J Epidemiol
Pays: England
ID NLM: 7802871
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
20
06
2019
accepted:
10
01
2020
pubmed:
18
3
2020
medline:
26
3
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
Small-area studies offer a powerful epidemiological approach to study disease patterns at the population level and assess health risks posed by environmental pollutants. They involve a public health investigation on a geographical scale (e.g. neighbourhood) with overlay of health, environmental, demographic and potential confounder data. Recent methodological advances, including Bayesian approaches, combined with fast-growing computational capabilities, permit more informative analyses than previously possible, including the incorporation of data at different scales, from satellites to individual-level survey information. Better data availability has widened the scope and utility of small-area studies, but has also led to greater complexity, including choice of optimal study area size and extent, duration of study periods, range of covariates and confounders to be considered and dealing with uncertainty. The availability of data from large, well-phenotyped cohorts such as UK Biobank enables the use of mixed-level study designs and the triangulation of evidence on environmental risks from small-area and individual-level studies, therefore improving causal inference, including use of linked biomarker and -omics data. As a result, there are now improved opportunities to investigate the impacts of environmental risk factors on human health, particularly for the surveillance and prevention of non-communicable diseases.
Identifiants
pubmed: 32182344
pii: 5809182
doi: 10.1093/ije/dyaa006
pmc: PMC7266556
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
686-699Subventions
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204535/Z/16/Z
Pays : United Kingdom
Organisme : Department of Health
ID : HPRU-2012–10141
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.
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