Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature.
Autoimmune encephalitis
Glioblastoma
Glioma
Limbic encephalitis
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
07 Mar 2020
07 Mar 2020
Historique:
received:
14
01
2020
revised:
05
03
2020
accepted:
07
03
2020
pubmed:
18
3
2020
medline:
18
3
2020
entrez:
18
3
2020
Statut:
aheadofprint
Résumé
A 43-year-old woman presented with cognitive decline, focal seizures, brain MRI showing non-enhancing, bilateral hippocampal lesions, but normal cerebrospinal fluid findings, which fulfilled the Graus et al., 2016 criteria for autoimmune limbic encephalitis (ALE). Subjective improvements were observed after immunotherapy. A repeat brain MRI showed new contrast enhancement and positron emission tomography revealed left hippocampal uptake. Biopsy of the right parahippocampus yielded high-grade glioma. Five similar cases, among the 14 with unilateral hippocampal lesions on MRI, were identified in the literature whereby suspected ALE preceded the high-grade glioma diagnosis. Gliomas confined to hippocampi can have clinical features overlapping with ALE.
Identifiants
pubmed: 32182452
pii: S0165-5728(20)30036-9
doi: 10.1016/j.jneuroim.2020.577214
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577214Informations de copyright
Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors report no conflicts of interest to disclose.