Meaning in life and risk of cognitive impairment: A 9-Year prospective study in 14 countries.
Cognitive impairment
Meaning in life
Purpose
SHARE
Journal
Archives of gerontology and geriatrics
ISSN: 1872-6976
Titre abrégé: Arch Gerontol Geriatr
Pays: Netherlands
ID NLM: 8214379
Informations de publication
Date de publication:
Historique:
received:
03
10
2019
revised:
31
01
2020
accepted:
17
02
2020
pubmed:
18
3
2020
medline:
4
11
2020
entrez:
18
3
2020
Statut:
ppublish
Résumé
A meaningful and purpose-driven life is associated with better health outcomes. We test whether meaning in life is associated with risk of cognitive impairment using data from a large, multi-national study. Participants (N = 22,514) were from the Survey of Health, Ageing and Retirement in Europe (SHARE). Participants from 14 countries reported on their meaning in life. Cognitive impairment was derived from performance on cognitive tasks administered at baseline and at up to three follow-up waves (waves 2-6 assessed between 2010-2015). Lack of meaning in life was associated with a more than 20 % increased risk of incident cognitive impairment over the up to 9-year follow-up (Hazard Ratio = 1.24; 95 % Confidence Interval = 1.17-1.31). Further, compared to participants who reported often feeling meaning in life, participants who reported never feeling meaning in life were at an approximately 75 % increased risk of impairment (Hazard Ratio = 1.75, 95 % Confidence Interval = 1.19-2.57). The association between meaning in life and risk of cognitive impairment was apparent across four regions of Europe (Northern, Southern, Eastern, Western) and in Israel and was not moderated by sociodemographic characteristics. Reporting lower meaning in one's life is associated with risk of incident cognitive impairment. Meaning may be a potential target of intervention for healthier cognitive aging.
Sections du résumé
BACKGROUND
A meaningful and purpose-driven life is associated with better health outcomes. We test whether meaning in life is associated with risk of cognitive impairment using data from a large, multi-national study.
METHODS
Participants (N = 22,514) were from the Survey of Health, Ageing and Retirement in Europe (SHARE). Participants from 14 countries reported on their meaning in life. Cognitive impairment was derived from performance on cognitive tasks administered at baseline and at up to three follow-up waves (waves 2-6 assessed between 2010-2015).
RESULTS
Lack of meaning in life was associated with a more than 20 % increased risk of incident cognitive impairment over the up to 9-year follow-up (Hazard Ratio = 1.24; 95 % Confidence Interval = 1.17-1.31). Further, compared to participants who reported often feeling meaning in life, participants who reported never feeling meaning in life were at an approximately 75 % increased risk of impairment (Hazard Ratio = 1.75, 95 % Confidence Interval = 1.19-2.57). The association between meaning in life and risk of cognitive impairment was apparent across four regions of Europe (Northern, Southern, Eastern, Western) and in Israel and was not moderated by sociodemographic characteristics.
CONCLUSIONS
Reporting lower meaning in one's life is associated with risk of incident cognitive impairment. Meaning may be a potential target of intervention for healthier cognitive aging.
Identifiants
pubmed: 32182537
pii: S0167-4943(20)30027-3
doi: 10.1016/j.archger.2020.104033
pmc: PMC7211110
mid: NIHMS1576781
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104033Subventions
Organisme : NIA NIH HHS
ID : HHSN271201300071C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053297
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG057917
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG064952
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None of the authors has a conflict of interest to report.
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