Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study.
DNA methylation
biomarker
biorepository
environmental exposures
epigenetics
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
09 03 2020
09 03 2020
Historique:
received:
15
02
2020
revised:
03
03
2020
accepted:
06
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
20
9
2020
Statut:
epublish
Résumé
Environmental factors have been linked to many diseases and health conditions, but reliable assessment of environmental exposures is challenging. Developing biomarkers of environmental exposures, rather than relying on self-report, will improve our ability to assess the association of such exposures with disease. Epigenetic markers, most notably DNA methylation, have been identified for some environmental exposures, but identification of markers for additional exposures is still needed. The rationale behind the Markers for Environmental Exposures (MEE) Study was to (1) identify biomarkers, especially epigenetic markers, of environmental exposures, such as pesticides, air/food/water contaminants, and industrial chemicals that are commonly encountered in the general population; and (2) support the study of potential relationships between environmental exposures and health and health-related factors. The MEE Study is a cross-sectional study with potential for record linkage and follow-up. The well-characterized cohort of 400 postmenopausal women has generated a repository of biospecimens, including blood, urine, and saliva samples. Paired data include an environmental exposures questionnaire, a breast health questionnaire, dietary recalls, and a food frequency questionnaire. This work describes the rationale, study design, and cohort characteristics of the MEE Study. In addition to our primary research goals, we hope that the data and biorepository generated by this study will serve as a resource for future studies and collaboration.
Identifiants
pubmed: 32182891
pii: ijerph17051774
doi: 10.3390/ijerph17051774
pmc: PMC7084413
pii:
doi:
Substances chimiques
Biomarkers
0
Pesticides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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