Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells.
basal cell carcinoma
metabolic markers
metformin
photodynamic therapy
resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Mar 2020
13 Mar 2020
Historique:
received:
31
01
2020
revised:
04
03
2020
accepted:
09
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
19
3
2020
Statut:
epublish
Résumé
Photodynamic Therapy (PDT) with methyl-aminolevulinate (MAL-PDT) is being used for the treatment of Basal Cell Carcinoma (BCC), although resistant cells may appear. Normal differentiated cells depend primarily on mitochondrial oxidative phosphorylation (OXPHOS) to generate energy, but cancer cells switch this metabolism to aerobic glycolysis (Warburg effect), influencing the response to therapies. We have analyzed the expression of metabolic markers (β-F1-ATPase/GAPDH (glyceraldehyde-3-phosphate dehydrogenase) ratio, pyruvate kinase M2 (PKM2), oxygen consume ratio, and lactate extracellular production) in the resistance to PDT of mouse BCC cell lines (named ASZ and CSZ, heterozygous for
Identifiants
pubmed: 32183017
pii: cancers12030668
doi: 10.3390/cancers12030668
pmc: PMC7139992
pii:
doi:
Types de publication
Journal Article
Langues
eng
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