C-Terminal 1-Aminoethyltetrazole-Containing Oligopeptides as Novel Alanine Racemase Inhibitors.
1-aminoethyltetrazole
alanine racemase
antibacterial agent
selective inhibition
solid phase peptide synthesis
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Mar 2020
13 Mar 2020
Historique:
received:
15
02
2020
revised:
05
03
2020
accepted:
09
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
17
12
2020
Statut:
epublish
Résumé
In clinical culture media inoculated with patient samples, selective inhibition of commensal bacteria is essential for accurate diagnosis and effective treatment, as they can mask the presence of pathogenic bacteria. The alanine analogue, 1-aminoethyltetrazole was investigated as a potential alanine racemase inhibitor. For effective uptake and enhanced and selective antibacterial activity, a library of C-terminal 1-aminoethyltetrazole containing di- and oligopeptides were synthesized by solid phase peptide coupling techniques. The investigation of the antimicrobial activity of the synthesised compounds identified several clinically applicable selective inhibitors. These enabled differentiation between the closely related bacteria,
Identifiants
pubmed: 32183087
pii: molecules25061315
doi: 10.3390/molecules25061315
pmc: PMC7145296
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Oligopeptides
0
Tetrazoles
0
Alanine Racemase
EC 5.1.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : bioMerieux
ID : n/a
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