Unraveling the Role of Inwardly Rectifying Potassium Channels in the Hippocampus of an Aβ
Alzheimer’s disease
K+ channels
Kir channels
amyloid beta
hippocampus
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Mar 2020
13 Mar 2020
Historique:
received:
07
02
2020
revised:
10
03
2020
accepted:
12
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
19
3
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir) channels are important for playing a key role in maintaining the resting membrane potential and controlling cell excitability, being largely expressed in both excitable and non-excitable tissues, including neurons. Accordingly, the aim of the study is to investigate the role of neuronal Kir channels in AD pathophysiology. The mRNA and protein levels of neuronal Kir2.1, Kir3.1, and Kir6.2 were evaluated by real-time PCR and Western blot analysis from the hippocampus of an amyloid-β(Aβ)
Identifiants
pubmed: 32183098
pii: biomedicines8030058
doi: 10.3390/biomedicines8030058
pmc: PMC7148495
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Bezmiâlem Vakif Üniversitesi
ID : 12.2014/2 and 9.2015/26
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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