Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.

Alzheimer Disease / drug therapy Antioxidants / chemistry Calcium / metabolism Calcium Channel Blockers / chemistry Calcium Channels / metabolism Cell Line, Tumor Dihydropyridines / chemistry Humans Ligands Monoamine Oxidase Inhibitors / chemistry Neuroprotection / drug effects Neuroprotective Agents / chemistry Nimodipine / chemistry
Alzheimer’s disease Ca2+ channel antagonists Hantzsch reaction multitarget directed ligands neuroprotection oxidative stress

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
14 Mar 2020
Historique:
received: 28 02 2020
revised: 12 03 2020
accepted: 12 03 2020
entrez: 19 3 2020
pubmed: 19 3 2020
medline: 15 12 2020
Statut: epublish

Résumé

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca

Identifiants

DOI: 10.3390/molecules25061329 PMID: 32183349 PMC: PMC7144121
pubmed: 32183349
pii: molecules25061329
doi: 10.3390/molecules25061329
pmc: PMC7144121
pii:
doi:

Substances chimiques

Antioxidants 0
Calcium Channel Blockers 0
Calcium Channels 0
Dihydropyridines 0
Ligands 0
Monoamine Oxidase Inhibitors 0
Neuroprotective Agents 0
Nimodipine 57WA9QZ5WH
1,4-dihydropyridine 7M8K3P6I89
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Regional Council of Franche-Comté
ID : 2016YC-04540 and 04560
Organisme : Foundation for Science and Technology; FEDER/COMPETE
ID : UID/QUI/00081/2020, PTDC/MED-QUI/29164/2017, and SFRH/BPD/114945/2016

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Auteurs

Irene Pachòn Angona (I)

Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.

Solene Daniel (S)

Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.

Helene Martin (H)

PEPITE EA4267, Laboratoire de Toxicologie Cellulaire, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.

Alexandre Bonet (A)

PEPITE EA4267, Laboratoire de Toxicologie Cellulaire, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.

Artur Wnorowski (A)

Department of Biopharmacy, Medical University of Lublin, ul. W. Chodzki 4a, 20-093 Lublin, Poland.
ORCID: 0000-0002-2258-4225

Maciej Maj (M)

Department of Biopharmacy, Medical University of Lublin, ul. W. Chodzki 4a, 20-093 Lublin, Poland.

Krzysztof Jóźwiak (K)

Department of Biopharmacy, Medical University of Lublin, ul. W. Chodzki 4a, 20-093 Lublin, Poland.

Tiago Barros Silva (TB)

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre 1021/1055, 4169-007 Porto, Portugal.

Bernard Refouvelet (B)

Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.

Fernanda Borges (F)

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre 1021/1055, 4169-007 Porto, Portugal.
ORCID: 0000-0003-1050-2402

José Marco-Contelles (J)

Laboratory of Medicinal Chemistry (IQOG, CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain.

Lhassane Ismaili (L)

Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Dihydropyridines › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Design, Synthesis and Biological Evaluation of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nimodipine › Design, Synthesis and Biological Evaluation of...