The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis.
TLR4
TNBS-induced colitis
bovine colostrum
cytokines
microbiota
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
15 Mar 2020
15 Mar 2020
Historique:
received:
06
02
2020
revised:
06
03
2020
accepted:
14
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
19
3
2020
Statut:
epublish
Résumé
This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12) administration in mice. Clinical signs, histopathological characteristics, expression levels of Toll-like receptor 4 (TLR4), pro- and anti-inflammatory cytokines, and microbial composition were assessed. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, the BC group showed a reduction in body weight (BW) loss compared to Control (
Identifiants
pubmed: 32183497
pii: ani10030492
doi: 10.3390/ani10030492
pmc: PMC7143345
pii:
doi:
Types de publication
Journal Article
Langues
eng
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