Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
17 03 2020
17 03 2020
Historique:
received:
13
05
2019
accepted:
20
12
2019
revised:
12
12
2019
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Low self-esteem is a risk factor for a range of psychiatric disorders. From a cognitive perspective a negative self-image can be maintained through aberrant learning about self-worth derived from social feedback. We previously showed that neural teaching signals that represent the difference between expected and actual social feedback (i.e., social prediction errors) drive fluctuations in self-worth. Here, we used model-based functional magnetic resonance imaging (fMRI) to characterize learning from social prediction errors in 61 participants drawn from a population-based sample (n = 2402) who were recruited on the basis of being in the bottom or top 10% of self-esteem scores. Participants performed a social evaluation task during fMRI scanning, which entailed predicting whether other people liked them as well as the repeated provision of reported feelings of self-worth. Computational modeling results showed that low self-esteem participants had persistent expectations that others would dislike them, and a reduced propensity to update these expectations in response to social prediction errors. Low self-esteem subjects also displayed an enhanced volatility in reported feelings of self-worth, and this was linked to an increased tendency for social prediction errors to determine momentary self-worth. Canonical correlation analysis revealed that individual differences in self-esteem related to several interconnected psychiatric symptoms organized around a single dimension of interpersonal vulnerability. Such interpersonal vulnerability was associated with an attenuated social value signal in ventromedial prefrontal cortex when making predictions about being liked, and enhanced dorsal prefrontal cortex activity upon receipt of social feedback. We suggest these computational signatures of low self-esteem and their associated neural underpinnings might represent vulnerability for development of psychiatric disorder.
Identifiants
pubmed: 32184384
doi: 10.1038/s41398-020-0702-4
pii: 10.1038/s41398-020-0702-4
pmc: PMC7078312
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
96Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : DH | National Institute for Health Research (NIHR)
ID : NF-SI-0514-10157
Pays : International
Organisme : Wellcome Trust (Wellcome)
ID : 095844/Z/11/Z
Pays : International
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/N02401X/1
Pays : International
Organisme : Medical Research Council
ID : MC_G0802534
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 707404
Pays : International
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