Translation of mouse model to human gives insights into periodontitis etiology.

Aggressive Periodontitis / etiology Animals Chronic Periodontitis / etiology Disease Models, Animal Genetic Predisposition to Disease / genetics Genome-Wide Association Study Genotype Humans Mice Models, Theoretical Quantitative Trait Loci / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
17 03 2020
Historique:
received: 03 06 2019
accepted: 03 03 2020
entrez: 19 3 2020
pubmed: 19 3 2020
medline: 18 11 2020
Statut: epublish

Résumé

To suggest candidate genes involved in periodontitis, we combined gene expression data of periodontal biopsies from Collaborative Cross (CC) mouse lines, with previous reported quantitative trait loci (QTL) in mouse and with human genome-wide association studies (GWAS) associated with periodontitis. Periodontal samples from two susceptible, two resistant and two lines that showed bone formation after periodontal infection were collected during infection and naïve status. Differential expressed genes (DEGs) were analyzed in a case-control and case-only design. After infection, eleven protein-coding genes were significantly stronger expressed in resistant CC lines compared to susceptible ones. Of these, the most upregulated genes were MMP20 (P = 0.001), RSPO4 (P = 0.032), CALB1 (P = 1.06×10

Identifiants

DOI: 10.1038/s41598-020-61819-0 PMID: 32184465 PMC: PMC7078197
pubmed: 32184465
doi: 10.1038/s41598-020-61819-0
pii: 10.1038/s41598-020-61819-0
pmc: PMC7078197
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4892

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Auteurs

Aysar Nashef (A)

Department of Prosthodontics, Dental school, The Hebrew University, Hadassah Jerusalem, Israel.
Department of Oral and Maxillofacial surgery, Poriya Medical center, Poriya, Israel.
Department of Clinical. Microbiology and Immunology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Munz Matthias (M)

Department of Periodontology and Synoptic Medicine, Institute for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany.
Institute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany.
ORCID: 0000-0002-4728-3357

Ervin Weiss (E)

School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Bruno G Loos (BG)

Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Søren Jepsen (S)

Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.

Nathalie van der Velde (N)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Internal Medicine section of Geriatrics, Amsterdam Medical Center, Amsterdam, The Netherlands.

André G Uitterlinden (AG)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-7276-3387

Jürgen Wellmann (J)

Institute of Epidemiology and Social Medicine, University Münster, Münster, Germany.

Klaus Berger (K)

Institute of Epidemiology and Social Medicine, University Münster, Münster, Germany.

Per Hoffmann (P)

Institute of Human Genetics, University of Bonn, Bonn, Germany.
Human Genomics Research Group, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland.
ORCID: 0000-0002-6573-983X

Matthias Laudes (M)

Department of Medicine, University of Kiel, Kiel, Germany.

Wolfgang Lieb (W)

Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany.

Andre Franke (A)

Institute of Clinical Molecular Biology, Christian-Albrechts-University, Berlin, Germany.
ORCID: 0000-0003-1530-5811

Henrik Dommisch (H)

Department of Oral and Maxillofacial surgery, Poriya Medical center, Poriya, Israel.

Arne Schäfer (A)

Department of Periodontology and Synoptic Medicine, Institute for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany. arne.schaefer@charite.de.
Institute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany. arne.schaefer@charite.de.
ORCID: 0000-0001-5816-6765

Yael Houri-Haddad (Y)

Department of Prosthodontics, Dental school, The Hebrew University, Hadassah Jerusalem, Israel. yaelho@ekmd.huji.ac.il.

Fuad A Iraqi (FA)

Department of Clinical. Microbiology and Immunology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. fuadi@post.tau.ac.il.
ORCID: 0000-0001-5525-206X

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Classifications MeSH

questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies parodontales › Parodontite › Parodontite agressive › Translation of mouse model to human gives...
questionsmedicales.fr › Eucaryotes › Animaux › Translation of mouse model to human gives...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Parodontite chronique › Translation of mouse model to human gives...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Translation of mouse model to human gives...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Translation of mouse model to human gives...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Translation of mouse model to human gives...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Translation of mouse model to human gives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Translation of mouse model to human gives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Translation of mouse model to human gives...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Translation of mouse model to human gives...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Translation of mouse model to human gives...