From Xanthine Oxidase Inhibition to
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
08
2019
revised:
10
12
2019
accepted:
24
12
2019
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
19
3
2020
Statut:
epublish
Résumé
Hyperuricemia is characterized by elevated uric acid (UA) levels on blood, which can lead to gout, a common pathology. These high UA levels are associated with increased purine ingestion and metabolization and/or its decreased excretion. In this field, xanthine oxidase (XO), by converting hypoxanthine and xanthine to UA, plays an important role in hyperuricemia control. Based on limitations and adverse effects associated with the use of allopurinol and febuxostat, the most known approved drugs with XO inhibitory effect, the search for new molecules with XO activity is growing. However, despite the high number of studies, it was found that the majority of tested products with relevant XO inhibition were left out, and no further pharmacological evaluation was performed. Thus, in the present review, available information published in the past six years concerning isolated molecules with
Identifiants
pubmed: 32184901
doi: 10.1155/2020/9531725
pmc: PMC7060854
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
9531725Informations de copyright
Copyright © 2020 João L. Serrano et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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