Association between Takayasu arteritis and ischemic heart disease: a cohort study.
Takayasu arteritis
immune diseases
ischemic heart disease
vasculitis
Journal
Mediterranean journal of rheumatology
ISSN: 2529-198X
Titre abrégé: Mediterr J Rheumatol
Pays: Greece
ID NLM: 101730166
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
03
05
2019
revised:
22
09
2019
accepted:
27
09
2019
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
19
3
2020
Statut:
epublish
Résumé
Takayasu arteritis (TA) is an idiopathic large vessel vasculitis, which involves the aorta and its major branches. Our aim was to examine the association between TA and the development of ischemic heart disease (IHD) and its impact on survival. Using data from Clalit Health Services (CHS), the largest Health Maintenance Organization (HMO) in Israel, the proportion of IHD was compared between patients diagnosed with TA and age- and gender-matched controls. Chi-square and t-tests were used for univariate analysis, and a logistic regression model was employed for multivariate analysis. Survival analysis was performed using Kaplan-Meier plots and cox regression. The study included 155 TA patients and 755 age- and gender-frequency matched controls. The proportion of IHD in TA patients was increased in comparison with controls (32.3% and 8.9%, p<0.001). In multivariate analysis, IHD was associated with TA (OR=6.576, 95% CI: 4.09-10.64) and male gender (OR=2.29, 95% CI: 1.43-4.26). Survival analysis over 15 years of follow-up showed a higher proportion of all-causes mortality in the TA group. In a multivariate analysis, TA (HR=2.58, 95%CI: 1.64-4.06) and IHD (HR=1.64, 95%CI: 1.05-2.55) were found to be associated with reduced survival. TA patients present an increased proportion of IHD, and a reduced 15-years survival rate compared to controls.
Identifiants
pubmed: 32185361
doi: 10.31138/mjr.30.3.171
pii: MJR-30-3-171
pmc: PMC7045855
doi:
Types de publication
Journal Article
Langues
eng
Pagination
171-176Informations de copyright
© 2019 The Mediterranean Journal of Rheumatology (MJR).
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