New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study.
Cataract surgery
Dry eye disease
Lubricating eye drops
Ocular surface
Ophthalmology
Journal
Advances in therapy
ISSN: 1865-8652
Titre abrégé: Adv Ther
Pays: United States
ID NLM: 8611864
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
28
01
2020
pubmed:
19
3
2020
medline:
15
12
2020
entrez:
19
3
2020
Statut:
ppublish
Résumé
To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT > 7, Schirmer I test > 15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo A total of 45 patients were included (group A, 23; group B, 22; age 74 ± 8 years). At the screening, TBUT was similar between the groups (group A, 8.5 ± 1.8 s; group B, 7.8 ± 0.7, p = 0.11). At the scheduled visits, TBUT increase vs screening visit was significantly higher in group A: +1.2 s at V0, +1.4 s at V1, and +1.9 s at V2 (p < 0.01). Also, OSDI was significantly lower in group A at V0, V1, and V2 (p < 0.027). After surgery, corneal staining was absent in 65-78% of group A compared with 54-59% in group B. The two groups did not show any significant differences of osmometry and the Schirmer I test. The ocular surface was more protected and quickly restored from surgery when VisuEvo ClinicalTrials.gov identifier, NCT03833908.
Identifiants
pubmed: 32185729
doi: 10.1007/s12325-020-01288-z
pii: 10.1007/s12325-020-01288-z
pmc: PMC7140734
doi:
Substances chimiques
Lubricant Eye Drops
0
Carboxymethylcellulose Sodium
K679OBS311
Banques de données
ClinicalTrials.gov
['NCT03833908']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1664-1674Références
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