Pain expectancy, prevalence, severity, and patterns following donor nephrectomy: Findings from the KDOC Study.
anesthesia/pain management
clinical research/practice
donors and donation
donors and donation: donor follow-up
donors and donation: living
health services and outcomes research
kidney transplantation/nephrology
kidney transplantation:living donor
quality of life (QOL)
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
22
11
2019
revised:
14
02
2020
accepted:
03
03
2020
pubmed:
19
3
2020
medline:
22
6
2021
entrez:
19
3
2020
Statut:
ppublish
Résumé
Postoperative pain is an outcome of importance to potential living kidney donors (LKDs). We prospectively characterized the prevalence, severity, and patterns of acute or chronic postoperative pain in 193 LKDs at six transplant programs. Three pain measurements were obtained from donors on postoperative Day (POD) 1, 3, 7, 14, 21, 28, 35, 41, 49, and 56. The median pain rating total was highest on POD1 and declined from each assessment to the next until reaching a median pain-free score of 0 on POD49. In generalized linear mixed-model analysis, the mean pain score decreased at each pain assessment compared to the POD3 assessment. Pre-donation history of mood disorder (adjusted ratio of means [95% confidence interval (CI)]: 1.40 [0.99, 1.98]), reporting "severe" on any POD1 pain descriptors (adjusted ratio of means [95% CI]: 1.47 [1.12, 1.93]) and open nephrectomy (adjusted ratio of means [95% CI]: 2.61 [1.03, 6.62]) were associated with higher pain scores across time. Of the 179 LKDs who completed the final pain assessment, 74 (41%) met criteria for chronic postsurgical pain (CPSP), that is, any donation-related pain on POD56. Study findings have potential implications for LKD education, surgical consent, postdonation care, and outcome measurements.
Identifiants
pubmed: 32185880
doi: 10.1111/ajt.15861
pmc: PMC7483675
mid: NIHMS1579186
pii: S1600-6135(22)22569-6
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2522-2529Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK085185
Pays : United States
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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