Prognostic relevance of a blastic plasmacytoid dendritic cell neoplasm-like immunophenotype in cytogenetically normal acute myeloid leukemia patients.

Dendritic Cells Humans Immunophenotyping Leukemia, Myeloid, Acute / diagnosis Middle Aged Mutation Nucleophosmin Prognosis
Acute myeloid leukemia NPM1-mutation blastic plasmacytoid dendritic cell neoplasms immunophenotype prognosis

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
07 2020
Historique:
pubmed: 19 3 2020
medline: 28 4 2021
entrez: 19 3 2020
Statut: ppublish

Résumé

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a poor prognosis myeloid malignancy characterized by an atypical phenotype (CD123+, CD56+, and CD4+). We reported that BPDCN-like phenotype (CD123+ and either CD56+ or CD4+ or both) confers poor prognosis to acute myeloblastic leukemia (AML) patients with mutated NPM1. Here, we evaluated the incidence and the prognostic relevance of BPDCN-like phenotype in cytogenetically normal AML (CN-AML) patients. From 2006 to 2016, 83 young (age <60 yrs), consecutive, CN-AML patients underwent intensive treatment. Fifteen patients (18%) showed a BPDCN-like phenotype with no difference between

Identifiants

DOI: 10.1080/10428194.2020.1737685 PMID: 32186422
pubmed: 32186422
doi: 10.1080/10428194.2020.1737685
doi:

Substances chimiques

NPM1 protein, human 0
Nucleophosmin 117896-08-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1695-1701

Auteurs

Fabio Guolo (F)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Paola Minetto (P)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Marino Clavio (M)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Riccardo Marcolin (R)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Maurizio Miglino (M)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Monica Passannante (M)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Fabrizio Caviglia (F)

Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Filippo Ballerini (F)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Elisabetta Tedone (E)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinical Flow Cytometry Unit, Department of Pathology, Ospedale Policlinico San Martino, Genoa, Italy.

Annalisa Kunkl (A)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinical Flow Cytometry Unit, Department of Pathology, Ospedale Policlinico San Martino, Genoa, Italy.

Rosa Mangerini (R)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinical Flow Cytometry Unit, Department of Pathology, Ospedale Policlinico San Martino, Genoa, Italy.

Paola Contini (P)

Clinical Flow Cytometry Unit, Department of Pathology, Ospedale Policlinico San Martino, Genoa, Italy.

Nicoletta Colombo (N)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinical Flow Cytometry Unit, Department of Pathology, Ospedale Policlinico San Martino, Genoa, Italy.

Antonia Cagnetta (A)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.

Michele Cea (M)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Enrico Carminati (E)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Girolamo Pugliese (G)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Marco Gobbi (M)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

Roberto Massimo Lemoli (RM)

Department of Oncology and Hematology, Ospedale Policlinico San Martino, Genoa, Italy.
Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Nucléophosmine › Prognostic relevance of a blastic plasmacytoid...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic relevance of a blastic plasmacytoid...