Establishment and Maintenance of the Macrophage Niche.
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
17 03 2020
17 03 2020
Historique:
received:
20
12
2019
revised:
21
02
2020
accepted:
24
02
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
21
7
2020
Statut:
ppublish
Résumé
Self-maintaining resident macrophages populate all mammalian organs. In addition to their role as immune sentinels, macrophages also perform day-to-day functions essential to tissue homeostasis. The homeostatic functions of macrophages are regulated by so-called tissular "niches" that control the size of the macrophage population and imprint tissue-specific identity. Here, we review the mechanisms underlying self-maintenance of distinct macrophage populations and outline the organizing principles of the macrophage niche. We examine recent studies that uncovered mutually beneficial cell-cell circuits established between macrophages and their niche and propose a modular view of tissues that integrates the resident macrophage as an essential component of each individual module. Manipulating macrophage niche cells to control the function of resident macrophages in vivo might have therapeutic value in various disease settings.
Identifiants
pubmed: 32187515
pii: S1074-7613(20)30086-8
doi: 10.1016/j.immuni.2020.02.015
pii:
doi:
Substances chimiques
IL34 protein, human
0
Interleukins
0
Macrophage Colony-Stimulating Factor
81627-83-0
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
434-451Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.