Different baseline characteristics are associated with incident wheeze in female and male adolescents.
adolescents
gender
incidence
obesity
wheeze
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
07
11
2019
revised:
19
02
2020
accepted:
16
03
2020
pubmed:
19
3
2020
medline:
15
5
2021
entrez:
19
3
2020
Statut:
ppublish
Résumé
To investigate the independent relationships between baseline characteristics and incident wheeze in adolescents, with particular regard to gender. Adolescents (N = 959), aged 12-15 years, answered a standardised respiratory questionnaire and underwent height and weight measurements at baseline. Four years later, 96% of the subjects completed a similar questionnaire. The present study included the adolescents without self-reported wheeze at baseline (n = 795; 394 girls). The proportion of adolescents with obesity was higher among subjects with incident wheeze than among subjects who never reported wheeze: 19.1% vs 8.3%. When stratifying for gender, this difference was only found in girls. In stepwise logistic regression models (odds ratios [95% confidence interval]), obesity (2.84 [1.17-6.86]) and rhinitis (3.04 [1.53-6.03]) at baseline and current smoking (2.60 [1.16-5.82]) at follow-up were associated with incident wheeze in girls. For boys, FEV Data stratified by gender showed that obesity in girls and an atopic constitution in boys were independently associated with increased risk of developing wheeze within four years.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2324-2331Informations de copyright
© 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Références
Wake M, Clifford SA, Patton GC, et al. Morbidity patterns among the underweight, overweight and obese between 2 and 18 years: population-based cross-sectional analyses. Int J Obes. 2013;37(Suppl 1):86-93.
Mitchell EA, Beasley R, Bjorksten B, Crane J, Garcia-Marcos L, Keil U. The association between BMI, vigorous physical activity and television viewing and the risk of symptoms of asthma, rhinoconjunctivitis and eczema in children and adolescents: ISAAC Phase Three. Clin Exp Allergy. 2013;43(Suppl 1):73-84.
Tollefsen E, Bjermer L, Langhammer A, Johnsen R, Holmen TL. Adolescent respiratory symptoms-girls are at risk: the Young-HUNT study, Norway. Respir Med. 2006;100(Suppl 3):471-476.
Forno E, Weiner DJ, Mullen J, et al. Obesity and airway dysanapsis in children with and without asthma. Am J Respir Crit Care Med. 2017;195(Suppl 3):314-323.
von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001;56(Suppl 11):835-838.
Weinmayr G, Forastiere F, Buchele G, Jaensch A, Strachan DP, Nagel G. Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two. PLoS ONE. 2014;9(Suppl 12):e113996.
van Veen IH, Ten Brinke A, Sterk PJ, Rabe KF, Bel EH. Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy. 2008;63(Suppl 5):570-574.
Nordvall SL, Janson C, Kalm-Stephens P, Foucard T, Toren K, Alving K. Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren. Allergy. 2005;60(Suppl 4):469-475.
Asher MI, Keil U, Anderson HR, et al. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8(Suppl 3):483-491.
Kalm-Stephens P, Nordvall L, Janson C, Neuman A, Malinovschi A, Alving K. Elevated exhaled nitric oxide in adolescents is associated with incident allergic symptoms: a prospective cohort study. J Investig Allergol Clin Immunol. 2019;29(Suppl 3):231-238.
Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J. 1997;10(Suppl 7):1683-1693.
Pedroletti C, Zetterquist W, Nordvall L, Alving K. Evaluation of exhaled nitric oxide in schoolchildren at different exhalation flow rates. Pediatr Res. 2002;52(Suppl 3):393-398.
Standardization of Spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med. 1995;152(Suppl 3):1107-1136.
Quanjer PH, Stanojevic S, Cole TJ, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(Suppl 6):1324-1343.
World Health Organization. Growth Reference Data for 5-19 Years. World Health Organization; 2007 [cited 2020 February 19]. Available from http://www.who.int/growthref/en
Lu KD, Billimek J, Bar-Yoseph R, Radom-Aizik S, Cooper DM, Anton-Culver H. Sex differences in the relationship between fitness and obesity on risk for asthma in adolescents. J Pediatr. 2016;176:36-42.
Schatz M, Camargo CA Jr. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann Allergy Asthma Immunol. 2003;91(Suppl 6):553-558.
Herrera-Trujillo M, Barraza-Villarreal A, Lazcano-Ponce E, Hernandez B, Sanin LH, Romieu I. Current wheezing, puberty, and obesity among Mexican adolescent females and young women. J Asthma. 2005;42(Suppl 8):705-709.
Kaplowitz PB. Link between body fat and the timing of puberty. Pediatrics. 2008;121(Suppl 3):208-217.
Lazzeri G, Tosti C, Pammolli A, et al. Overweight and lower age at menarche: evidence from the Italian HBSC cross-sectional survey. BMC Womens Health. 2018;18(Suppl 1):168.
Winkvist A, Hulten B, Kim JL, et al. Dietary intake, leisure time activities and obesity among adolescents in Western Sweden: a cross-sectional study. Nutr J. 2016;15:41.
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999;282(Suppl 22):2131-2135.
Scott HA, Gibson PG, Garg ML, Wood LG. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J. 2011;38(Suppl 3):594-602.
Ekstrom S, Hallberg J, Kull I, et al. Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study. Thorax. 2018;73(Suppl 6):538-545.
Jensen ME, Gibson PG, Collins CE, Wood LG. Airway and systemic inflammation in obese children with asthma. Eur Respir J. 2013;42(Suppl 4):1012-1019.
Malinovschi A, Janson C, Borres M, Alving K. Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity. J Allergy Clin Immunol. 2016;138(Suppl 5):1301-1308.
Genuneit J, Weinmayr G, Radon K, et al. Smoking and the incidence of asthma during adolescence: results of a large cohort study in Germany. Thorax. 2006;61(Suppl 7):572-578.