GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness.
AKT
BDNF
GSK3β
MDD
anti-depressants
depression
neuroprotection
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 03 2020
16 03 2020
Historique:
received:
04
02
2020
revised:
12
03
2020
accepted:
14
03
2020
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is suggested to be engaged in the pathogenesis of major depressive disorder, and to be a target and/or modifier of anti-depressants' action. In this review, we discuss abnormalities in the activity of GSK3β and its upstream regulators in different brain regions during depressive episodes. Additionally, putative role(s) of GSK3β in the pathogenesis of depression and the influence of anti-depressants on GSK3β activity are discussed.
Identifiants
pubmed: 32188010
pii: cells9030727
doi: 10.3390/cells9030727
pmc: PMC7140610
pii:
doi:
Substances chimiques
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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