The Predictive Value of Salt Sensitivity and Osmotic Fragility in the Development of Cerebral Small Vessel Disease.
Na+/K+-ATPase
cerebral small vessel disease
glycocalyx
osmotic fragility
salt sensitivity
white matter hyperintensities
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Mar 2020
16 Mar 2020
Historique:
received:
18
02
2020
revised:
14
03
2020
accepted:
15
03
2020
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Increased salt intake in food probably affects the progression of cerebral small vessel disease (CSVD), which justifies the study of disturbances in sodium homeostasis associated with the development of CSVD. We aimed to clarify the role of salt sensitivity and osmotic fragility in the development of CSVD. Erythrocyte salt sensitivity was measured using the modified salt blood test, and osmotic fragility was measured using the classic osmotic fragility test in 73 patients with CSVD (48 women; 60.1 ± 6.5 years) and 19 healthy volunteers (14 women; 56.9 ± 6.4 years). Salt sensitivity and osmotic fragility exhibited a predictive value in relation to CSVD. These parameters were associated with an increase in white matter hyperintensities (
Identifiants
pubmed: 32188149
pii: ijms21062036
doi: 10.3390/ijms21062036
pmc: PMC7139682
pii:
doi:
Substances chimiques
Sodium Chloride, Dietary
0
Sodium Chloride
451W47IQ8X
Sodium
9NEZ333N27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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