SUMOylation in development and neurodegeneration.

Animals Growth and Development / genetics Humans Nerve Degeneration / genetics Neurodegenerative Diseases / genetics Neurogenesis / genetics Plant Development / physiology Protein Processing, Post-Translational / physiology Signal Transduction / genetics Sumoylation / physiology
Epigenetics Neurodegenerative disorder Post-translational protein modification SUMO Signal transduction Ubiquitin-like protein

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
18 03 2020
Historique:
entrez: 20 3 2020
pubmed: 20 3 2020
medline: 29 10 2020
Statut: epublish

Résumé

In essentially all eukaryotes, proteins can be modified by the attachment of small ubiquitin-related modifier (SUMO) proteins to lysine side chains to produce branched proteins. This process of 'SUMOylation' plays essential roles in plant and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription. In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorders, focusing on Parkinson's disease and cerebral ischemia. Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of neuronal stem cells.

Identifiants

DOI: 10.1242/dev.175703 PMID: 32188601 PMC: PMC7097199
pubmed: 32188601
pii: 147/6/dev175703
doi: 10.1242/dev.175703
pmc: PMC7097199
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM063596
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH119020
Pays : United States
Organisme : NIGMS NIH HHS
ID : T34 GM008563
Pays : United States

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

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Auteurs

Tak-Yu Yau (TY)

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1569, USA.

Oscar Molina (O)

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1569, USA.

Albert J Courey (AJ)

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1569, USA courey@chem.ucla.edu.
ORCID: 0000-0002-4840-1407

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dégénérescence nerveuse › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes physiologiques des plantes › Développement des plantes › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › SUMOylation in development and neurodegeneration.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Sumoylation › SUMOylation in development and neurodegeneration.