HHV-6: an unusual cause of cerebellar ataxia.
Aged
Antiviral Agents
/ therapeutic use
Cerebellar Ataxia
/ complications
Diagnosis, Differential
Encephalitis, Viral
/ complications
Female
Ganciclovir
/ therapeutic use
Herpesvirus 6, Human
/ isolation & purification
Humans
Immunocompromised Host
Magnetic Resonance Imaging
Roseolovirus Infections
/ complications
brain stem / cerebellum
immunology
infections
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
17 Mar 2020
17 Mar 2020
Historique:
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
25
11
2020
Statut:
epublish
Résumé
Human herpesvirus 6 (HHV-6) infection is the cause of roseola infantum in children. The reactivation of HHV-6 is associated with multiple clinical syndromes including encephalitis and myelitis, especially in haematopoietic stem cell transplant recipients. However, the virus can cause encephalitis in other immunosuppressed as well as immunocompetent individuals. We report a case of a 70-year-old woman who was immunocompromised secondary to treatment of rheumatoid arthritis with leflunomide and methotrexate. The patient presented with acute ataxia, diplopia and dysarthria. MRI brain showed an enhancing lesion in the midbrain. The diagnosis of HHV-6 encephalitis was made after HHV-6 A DNA was detected in both serum and cerebrospinal fluid. Treatment consisted of a 3-week course of intravenous ganciclovir along with physiotherapy. At a 3-month follow-up, repeat MRI brain showed a decrease in size and oedema of the lesion and the patient's neurological function was improved.
Identifiants
pubmed: 32188617
pii: 13/3/e234303
doi: 10.1136/bcr-2020-234303
pmc: PMC7078691
pii:
doi:
Substances chimiques
Antiviral Agents
0
Ganciclovir
P9G3CKZ4P5
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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