Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization.


Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
06 2020
Historique:
received: 14 11 2019
revised: 15 02 2020
accepted: 12 03 2020
pubmed: 20 3 2020
medline: 1 10 2021
entrez: 20 3 2020
Statut: ppublish

Résumé

Although mutations in the gene encoding the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here, we characterize 98 tumors and 12 isogenic cell lines harboring

Identifiants

pubmed: 32188705
pii: 2159-8290.CD-19-1330
doi: 10.1158/2159-8290.CD-19-1330
pmc: PMC8188517
mid: NIHMS1578078
doi:

Substances chimiques

Phosphoproteins 0
RNA Splicing Factors 0
SF3B1 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

806-821

Subventions

Organisme : NCI NIH HHS
ID : R01 CA185486
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA179044
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128239
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA193313
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087497
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA218896
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Zhaoqi Liu (Z)

Program for Mathematical Genomics, Columbia University, New York, New York.
Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.

Akihide Yoshimi (A)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. rr2579@cumc.columbia.edu yoshimia@mskcc.org.

Jiguang Wang (J)

Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.

Hana Cho (H)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Stanley Chun-Wei Lee (S)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Michelle Ki (M)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Lillian Bitner (L)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Timothy Chu (T)

Program for Mathematical Genomics, Columbia University, New York, New York.
Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.

Harshal Shah (H)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Bo Liu (B)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Anthony R Mato (AR)

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Peter Ruvolo (P)

Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Giulia Fabbri (G)

Institute for Cancer Genetics, Columbia University, New York, New York.

Laura Pasqualucci (L)

Institute for Cancer Genetics, Columbia University, New York, New York.
Department of Pathology and Cell Biology, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

Omar Abdel-Wahab (O)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Raul Rabadan (R)

Program for Mathematical Genomics, Columbia University, New York, New York. rr2579@cumc.columbia.edu yoshimia@mskcc.org.
Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.

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