Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
Amino Acid Sequence
Animals
Coronavirus Infections
/ virology
Host-Pathogen Interactions
Interferon Type I
/ metabolism
Macrophages
/ immunology
Mice
Models, Molecular
Murine hepatitis virus
/ pathogenicity
Mutagenesis
Protein Conformation
Structure-Activity Relationship
Ubiquitination
Viral Proteins
/ chemistry
Virulence
Virus Replication
DUB activity
IFN antagonist
PLP2
PLP2 structure
coronavirus
papain-like protease
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
18 05 2020
18 05 2020
Historique:
received:
08
10
2019
accepted:
09
03
2020
pubmed:
20
3
2020
medline:
12
9
2020
entrez:
20
3
2020
Statut:
epublish
Résumé
Coronaviruses express a multifunctional papain-like protease, termed papain-like protease 2 (PLP2). PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiquitinating (DUB) enzyme which removes ubiquitin (Ub) moieties from ubiquitin-conjugated proteins. Previous
Identifiants
pubmed: 32188728
pii: JVI.01734-19
doi: 10.1128/JVI.01734-19
pmc: PMC7269429
pii:
doi:
Substances chimiques
Interferon Type I
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085089
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM132024
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007508
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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